Sat-Nav for T cells: Role of PI3K isoforms and lipid phosphatases in migration of T lymphocytes

Stephen G Ward; J Westwick; S Harris

doi:10.1016/j.imlet.2011.02.007

Sat-Nav for T cells: Role of PI3K isoforms and lipid phosphatases in migration of T lymphocytes

Stephen G Ward, J Westwick, S Harris

Department of Life Sciences

Research output: Contribution to journal › Article › peer-review

22 Citations (SciVal)

Abstract

Phosphoinositide 3-kinase (PI3K)-dependent signaling has been placed at the heart of conserved biochemical mechanisms that facilitate cell migration of leukocytes in response to a range of chemoattractant stimuli. This review assesses the evidence for and against PI3K-dependent mechanisms of T lymphocyte migration and whether pharmacological targeting of PI3K isoforms is likely to offer potential benefit for T cell mediated pathologies.

Original language	English
Pages (from-to)	15-18
Number of pages	4
Journal	Immunology Letters
Volume	138
Issue number	1
DOIs	https://doi.org/10.1016/j.imlet.2011.02.007
Publication status	Published - Jul 2011

Keywords

migration
inhibitors
T lymphocytes
PI3K

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10.1016/j.imlet.2011.02.007

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title = "Sat-Nav for T cells: Role of PI3K isoforms and lipid phosphatases in migration of T lymphocytes",

abstract = "Phosphoinositide 3-kinase (PI3K)-dependent signaling has been placed at the heart of conserved biochemical mechanisms that facilitate cell migration of leukocytes in response to a range of chemoattractant stimuli. This review assesses the evidence for and against PI3K-dependent mechanisms of T lymphocyte migration and whether pharmacological targeting of PI3K isoforms is likely to offer potential benefit for T cell mediated pathologies.",

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AU - Ward, Stephen G

AU - Westwick, J

AU - Harris, S

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AB - Phosphoinositide 3-kinase (PI3K)-dependent signaling has been placed at the heart of conserved biochemical mechanisms that facilitate cell migration of leukocytes in response to a range of chemoattractant stimuli. This review assesses the evidence for and against PI3K-dependent mechanisms of T lymphocyte migration and whether pharmacological targeting of PI3K isoforms is likely to offer potential benefit for T cell mediated pathologies.

KW - migration

KW - inhibitors

KW - T lymphocytes

KW - PI3K

UR - https://www.scopus.com/pages/publications/79957669550

UR - http://dx.doi.org/10.1016/j.imlet.2011.02.007

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DO - 10.1016/j.imlet.2011.02.007

M3 - Article

SN - 0165-2478

VL - 138

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EP - 18

JO - Immunology Letters

JF - Immunology Letters

IS - 1

ER -

Sat-Nav for T cells: Role of PI3K isoforms and lipid phosphatases in migration of T lymphocytes

Abstract

Keywords

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