Sat-Nav for T cells: Role of PI3K isoforms and lipid phosphatases in migration of T lymphocytes

Stephen G Ward; J Westwick; S Harris

doi:10.1016/j.imlet.2011.02.007

Sat-Nav for T cells: Role of PI3K isoforms and lipid phosphatases in migration of T lymphocytes

Stephen G Ward, J Westwick, S Harris

Department of Life Sciences

Research output: Contribution to journal › Article › peer-review

17 Citations (SciVal)

Abstract

Phosphoinositide 3-kinase (PI3K)-dependent signaling has been placed at the heart of conserved biochemical mechanisms that facilitate cell migration of leukocytes in response to a range of chemoattractant stimuli. This review assesses the evidence for and against PI3K-dependent mechanisms of T lymphocyte migration and whether pharmacological targeting of PI3K isoforms is likely to offer potential benefit for T cell mediated pathologies.

Original language	English
Pages (from-to)	15-18
Number of pages	4
Journal	Immunology Letters
Volume	138
Issue number	1
DOIs	https://doi.org/10.1016/j.imlet.2011.02.007
Publication status	Published - Jul 2011

Keywords

migration
inhibitors
T lymphocytes
PI3K

Access to Document

10.1016/j.imlet.2011.02.007

Cite this

@article{566ef67862e440e6b9300ca9da0dfe58,

title = "Sat-Nav for T cells: Role of PI3K isoforms and lipid phosphatases in migration of T lymphocytes",

abstract = "Phosphoinositide 3-kinase (PI3K)-dependent signaling has been placed at the heart of conserved biochemical mechanisms that facilitate cell migration of leukocytes in response to a range of chemoattractant stimuli. This review assesses the evidence for and against PI3K-dependent mechanisms of T lymphocyte migration and whether pharmacological targeting of PI3K isoforms is likely to offer potential benefit for T cell mediated pathologies.",

keywords = "migration, inhibitors, T lymphocytes, PI3K",

author = "Ward, {Stephen G} and J Westwick and S Harris",

year = "2011",

month = jul,

doi = "10.1016/j.imlet.2011.02.007",

language = "English",

volume = "138",

pages = "15--18",

journal = "Immunology Letters",

issn = "0165-2478",

publisher = "Elsevier",

number = "1",

}

TY - JOUR

T1 - Sat-Nav for T cells: Role of PI3K isoforms and lipid phosphatases in migration of T lymphocytes

AU - Ward, Stephen G

AU - Westwick, J

AU - Harris, S

PY - 2011/7

Y1 - 2011/7

N2 - Phosphoinositide 3-kinase (PI3K)-dependent signaling has been placed at the heart of conserved biochemical mechanisms that facilitate cell migration of leukocytes in response to a range of chemoattractant stimuli. This review assesses the evidence for and against PI3K-dependent mechanisms of T lymphocyte migration and whether pharmacological targeting of PI3K isoforms is likely to offer potential benefit for T cell mediated pathologies.

AB - Phosphoinositide 3-kinase (PI3K)-dependent signaling has been placed at the heart of conserved biochemical mechanisms that facilitate cell migration of leukocytes in response to a range of chemoattractant stimuli. This review assesses the evidence for and against PI3K-dependent mechanisms of T lymphocyte migration and whether pharmacological targeting of PI3K isoforms is likely to offer potential benefit for T cell mediated pathologies.

KW - migration

KW - inhibitors

KW - T lymphocytes

KW - PI3K

UR - http://www.scopus.com/inward/record.url?scp=79957669550&partnerID=8YFLogxK

UR - http://dx.doi.org/10.1016/j.imlet.2011.02.007

U2 - 10.1016/j.imlet.2011.02.007

DO - 10.1016/j.imlet.2011.02.007

M3 - Article

SN - 0165-2478

VL - 138

SP - 15

EP - 18

JO - Immunology Letters

JF - Immunology Letters

IS - 1

ER -

Sat-Nav for T cells: Role of PI3K isoforms and lipid phosphatases in migration of T lymphocytes

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this