Sat-Nav for T cells: Role of PI3K isoforms and lipid phosphatases in migration of T lymphocytes

Stephen G Ward, J Westwick, S Harris

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Phosphoinositide 3-kinase (PI3K)-dependent signaling has been placed at the heart of conserved biochemical mechanisms that facilitate cell migration of leukocytes in response to a range of chemoattractant stimuli. This review assesses the evidence for and against PI3K-dependent mechanisms of T lymphocyte migration and whether pharmacological targeting of PI3K isoforms is likely to offer potential benefit for T cell mediated pathologies.
Original languageEnglish
Pages (from-to)15-18
Number of pages4
JournalImmunology Letters
Volume138
Issue number1
DOIs
Publication statusPublished - Jul 2011

Fingerprint

1-Phosphatidylinositol 4-Kinase
Phosphoric Monoester Hydrolases
Protein Isoforms
T-Lymphocytes
Lipids
Chemotactic Factors
Cell Movement
Leukocytes
Pharmacology
Pathology

Keywords

  • migration
  • inhibitors
  • T lymphocytes
  • PI3K

Cite this

Sat-Nav for T cells: Role of PI3K isoforms and lipid phosphatases in migration of T lymphocytes. / Ward, Stephen G; Westwick, J; Harris, S.

In: Immunology Letters, Vol. 138, No. 1, 07.2011, p. 15-18.

Research output: Contribution to journalArticle

@article{566ef67862e440e6b9300ca9da0dfe58,
title = "Sat-Nav for T cells: Role of PI3K isoforms and lipid phosphatases in migration of T lymphocytes",
abstract = "Phosphoinositide 3-kinase (PI3K)-dependent signaling has been placed at the heart of conserved biochemical mechanisms that facilitate cell migration of leukocytes in response to a range of chemoattractant stimuli. This review assesses the evidence for and against PI3K-dependent mechanisms of T lymphocyte migration and whether pharmacological targeting of PI3K isoforms is likely to offer potential benefit for T cell mediated pathologies.",
keywords = "migration, inhibitors, T lymphocytes, PI3K",
author = "Ward, {Stephen G} and J Westwick and S Harris",
year = "2011",
month = "7",
doi = "10.1016/j.imlet.2011.02.007",
language = "English",
volume = "138",
pages = "15--18",
journal = "Immunology Letters",
issn = "0165-2478",
publisher = "Elsevier",
number = "1",

}

TY - JOUR

T1 - Sat-Nav for T cells: Role of PI3K isoforms and lipid phosphatases in migration of T lymphocytes

AU - Ward, Stephen G

AU - Westwick, J

AU - Harris, S

PY - 2011/7

Y1 - 2011/7

N2 - Phosphoinositide 3-kinase (PI3K)-dependent signaling has been placed at the heart of conserved biochemical mechanisms that facilitate cell migration of leukocytes in response to a range of chemoattractant stimuli. This review assesses the evidence for and against PI3K-dependent mechanisms of T lymphocyte migration and whether pharmacological targeting of PI3K isoforms is likely to offer potential benefit for T cell mediated pathologies.

AB - Phosphoinositide 3-kinase (PI3K)-dependent signaling has been placed at the heart of conserved biochemical mechanisms that facilitate cell migration of leukocytes in response to a range of chemoattractant stimuli. This review assesses the evidence for and against PI3K-dependent mechanisms of T lymphocyte migration and whether pharmacological targeting of PI3K isoforms is likely to offer potential benefit for T cell mediated pathologies.

KW - migration

KW - inhibitors

KW - T lymphocytes

KW - PI3K

UR - http://www.scopus.com/inward/record.url?scp=79957669550&partnerID=8YFLogxK

UR - http://dx.doi.org/10.1016/j.imlet.2011.02.007

U2 - 10.1016/j.imlet.2011.02.007

DO - 10.1016/j.imlet.2011.02.007

M3 - Article

VL - 138

SP - 15

EP - 18

JO - Immunology Letters

JF - Immunology Letters

SN - 0165-2478

IS - 1

ER -