Sat-Nav for T cells: Role of PI3K isoforms and lipid phosphatases in migration of T lymphocytes

Stephen G Ward, J Westwick, S Harris

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Phosphoinositide 3-kinase (PI3K)-dependent signaling has been placed at the heart of conserved biochemical mechanisms that facilitate cell migration of leukocytes in response to a range of chemoattractant stimuli. This review assesses the evidence for and against PI3K-dependent mechanisms of T lymphocyte migration and whether pharmacological targeting of PI3K isoforms is likely to offer potential benefit for T cell mediated pathologies.
Original languageEnglish
Pages (from-to)15-18
Number of pages4
JournalImmunology Letters
Volume138
Issue number1
DOIs
Publication statusPublished - Jul 2011

Keywords

  • migration
  • inhibitors
  • T lymphocytes
  • PI3K

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