Ruthenium-catalyzed remote electronic activation of aromatic C-F bonds

A.J.A. Watson; B.N. Atkinson; A.C. Maxwell; Jonathan M J Williams

doi:10.1002/adsc.201200879

Ruthenium-catalyzed remote electronic activation of aromatic C-F bonds

A.J.A. Watson, B.N. Atkinson, A.C. Maxwell, Jonathan M J Williams

GlaxoSmithKline

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13 Citations (SciVal)

Abstract

The tandem isomerization and nucleophilic aromatic substitution of allylic fluoro-substituted benzylic alcohols is described for the first time. In the presence of the ruthenium complex Ru(PPh3)3(CO)(H) 2, 1-(4-fluorophenyl)prop-2-en-1-ol is converted into the corresponding para-amino ketone or para-phenolic substituted ketone.

Original language	English
Pages (from-to)	734-740
Number of pages	7
Journal	Advanced Synthesis & Catalysis
Volume	355
Issue number	4
Early online date	22 Feb 2013
DOIs	https://doi.org/10.1002/adsc.201200879
Publication status	Published - 11 Mar 2013

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10.1002/adsc.201200879

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title = "Ruthenium-catalyzed remote electronic activation of aromatic C-F bonds",

abstract = "The tandem isomerization and nucleophilic aromatic substitution of allylic fluoro-substituted benzylic alcohols is described for the first time. In the presence of the ruthenium complex Ru(PPh3)3(CO)(H) 2, 1-(4-fluorophenyl)prop-2-en-1-ol is converted into the corresponding para-amino ketone or para-phenolic substituted ketone. ",

author = "A.J.A. Watson and B.N. Atkinson and A.C. Maxwell and Williams, \{Jonathan M J\}",

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AU - Watson, A.J.A.

AU - Atkinson, B.N.

AU - Maxwell, A.C.

AU - Williams, Jonathan M J

PY - 2013/3/11

Y1 - 2013/3/11

N2 - The tandem isomerization and nucleophilic aromatic substitution of allylic fluoro-substituted benzylic alcohols is described for the first time. In the presence of the ruthenium complex Ru(PPh3)3(CO)(H) 2, 1-(4-fluorophenyl)prop-2-en-1-ol is converted into the corresponding para-amino ketone or para-phenolic substituted ketone.

AB - The tandem isomerization and nucleophilic aromatic substitution of allylic fluoro-substituted benzylic alcohols is described for the first time. In the presence of the ruthenium complex Ru(PPh3)3(CO)(H) 2, 1-(4-fluorophenyl)prop-2-en-1-ol is converted into the corresponding para-amino ketone or para-phenolic substituted ketone.

UR - https://www.scopus.com/pages/publications/84874676733

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DO - 10.1002/adsc.201200879

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JF - Advanced Synthesis & Catalysis

IS - 4

ER -

Ruthenium-catalyzed remote electronic activation of aromatic C-F bonds

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Ruthenium-catalyzed remote electronic activation of aromatic C-F bonds

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