Ruthenium catalyzed remote C4-selective C–H functionalisation of carbazoles via σ-activation

Jamie A. Leitch; Callum J. Heron; Janette Mcknight; Gabriele Kociok-Köhn; Yunas Bhonoah; Christopher G. Frost

doi:10.1039/C7CC07606A

Ruthenium catalyzed remote C4-selective C–H functionalisation of carbazoles via σ-activation

Jamie A. Leitch
, Callum J. Heron
, Janette Mcknight
, Gabriele Kociok-Köhn
, Yunas Bhonoah
, Christopher G. Frost

Syngenta Ltd

Research output: Contribution to journal › Article › peer-review

44 Citations (SciVal)

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Abstract

We report the C4-selective C–H alkylation of carbazole derivatives furnished with a pyrimidine directing group at N9. This was realized using ruthenium catalyzed r-activation methodology, whereby C–H activation at C1 enables the interaction of this ruthenacycle, at the para position to the metal center, with tertiary alkyl radicals

Original language	English
Number of pages	4
Journal	Chemical Communications
Early online date	16 Nov 2017
DOIs	https://doi.org/10.1039/C7CC07606A
Publication status	Published - 18 Dec 2017

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10.1039/C7CC07606ALicence: CC BY

Final Manuscript
The final publication is available at the Royal Society of Chemistry via 10.1039/C7CC07606A
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title = "Ruthenium catalyzed remote C4-selective C–H functionalisation of carbazoles via σ-activation",

abstract = "We report the C4-selective C–H alkylation of carbazole derivatives furnished with a pyrimidine directing group at N9. This was realized using ruthenium catalyzed r-activation methodology, whereby C–H activation at C1 enables the interaction of this ruthenacycle, at the para position to the metal center, with tertiary alkyl radicals",

author = "Leitch, \{Jamie A.\} and Heron, \{Callum J.\} and Janette Mcknight and Gabriele Kociok-K{\"o}hn and Yunas Bhonoah and Frost, \{Christopher G.\}",

year = "2017",

month = dec,

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doi = "10.1039/C7CC07606A",

language = "English",

journal = "Chemical Communications",

issn = "1359-7345",

publisher = "Royal Society of Chemistry",

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T1 - Ruthenium catalyzed remote C4-selective C–H functionalisation of carbazoles via σ-activation

AU - Leitch, Jamie A.

AU - Heron, Callum J.

AU - Mcknight, Janette

AU - Kociok-Köhn, Gabriele

AU - Bhonoah, Yunas

AU - Frost, Christopher G.

PY - 2017/12/18

Y1 - 2017/12/18

N2 - We report the C4-selective C–H alkylation of carbazole derivatives furnished with a pyrimidine directing group at N9. This was realized using ruthenium catalyzed r-activation methodology, whereby C–H activation at C1 enables the interaction of this ruthenacycle, at the para position to the metal center, with tertiary alkyl radicals

AB - We report the C4-selective C–H alkylation of carbazole derivatives furnished with a pyrimidine directing group at N9. This was realized using ruthenium catalyzed r-activation methodology, whereby C–H activation at C1 enables the interaction of this ruthenacycle, at the para position to the metal center, with tertiary alkyl radicals

UR - http://doi.org/10.1039/C7CC07606A

U2 - 10.1039/C7CC07606A

DO - 10.1039/C7CC07606A

M3 - Article

SN - 1359-7345

JO - Chemical Communications

JF - Chemical Communications

ER -

Ruthenium catalyzed remote C4-selective C–H functionalisation of carbazoles via σ-activation

Abstract

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