Ruthenium catalyzed remote C4-selective C–H functionalisation of carbazoles via σ-activation

Jamie A. Leitch, Callum J. Heron, Janette Mcknight, Gabriele Kociok-Köhn, Yunas Bhonoah, Christopher G. Frost

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We report the C4-selective C–H alkylation of carbazole derivatives furnished with a pyrimidine directing group at N9. This was realized using ruthenium catalyzed r-activation methodology, whereby C–H activation at C1 enables the interaction of this ruthenacycle, at the para position to the metal center, with tertiary alkyl radicals
Original languageEnglish
Number of pages4
JournalChemical Communications
Early online date16 Nov 2017
Publication statusPublished - 18 Dec 2017


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