Ruthenium-catalyzed ortho-alkylation of phenols with alcohols by dehydrative coupling

J.W. Walton, Jonathan M J Williams

Research output: Contribution to journalArticle

20 Citations (Scopus)


Only water: Phenols have been shown to undergo a ruthenium-catalyzed ortho-alkylation reaction (see scheme; Cy=cyclohexyl). Unactivated alcohols are used as the alkylating agents and water is the only by-product that is generated, making this transformation more atom-economical and greener than traditional methods.
Original languageEnglish
Pages (from-to)12166-12168
Number of pages3
JournalAngewandte Chemie-International Edition
Issue number49
Publication statusPublished - 3 Dec 2012


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