Ruthenium-catalyzed conversion of 1,4-alkynediols into pyrroles

Simon J Pridmore, Paul A Slatford, Aurelie Daniel, Michael K Whittlesey, Jonathan M J Williams

Research output: Contribution to journalArticle

Abstract

Various 1,2,5-substituted pyrroles were synthesized from 1,4-alkynediols using a ruthenium-catalyzed isomerization to give the corresponding 1,4-dicarbonyl compds., which undergo in situ cyclization to pyrroles in the presence of amine.
Original languageEnglish
Pages (from-to)5115-5120
Number of pages6
JournalTetrahedron Letters
Volume48
Issue number29
Publication statusPublished - 2007

Keywords

  • Glycols Role
  • Ketones Role
  • Heterocyclization catalysts
  • Isomerization
  • RCT (Reactant)
  • Isomerization catalysts (prepn. of pyrroles by ruthenium-catalyzed tandem isomerization/cyclization of alkynediols with amines)
  • 4-
  • 1
  • PREP (Preparation) (diketones
  • alkynediol amine tandem isomerization heterocyclization ruthenium catalyst
  • RACT (Reactant or reagent) (alkynyl
  • pyrrole prepn
  • RACT (Reactant or reagent) (primary
  • Alcohols Role
  • Heterocyclization
  • Amines Role
  • prepn. of pyrroles by ruthenium-catalyzed tandem isomerization/cyclization of alkynediols with amines)
  • RACT (Reactant or reagent) (1
  • SPN (Synthetic preparation)

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  • Cite this

    Pridmore, S. J., Slatford, P. A., Daniel, A., Whittlesey, M. K., & Williams, J. M. J. (2007). Ruthenium-catalyzed conversion of 1,4-alkynediols into pyrroles. Tetrahedron Letters, 48(29), 5115-5120.