Ruthenium-catalyzed conversion of 1,4-alkynediols into pyrroles

Simon J Pridmore; Paul A Slatford; Aurelie Daniel; Michael K Whittlesey; Jonathan M J Williams

Ruthenium-catalyzed conversion of 1,4-alkynediols into pyrroles

Simon J Pridmore, Paul A Slatford, Aurelie Daniel, Michael K Whittlesey, Jonathan M J Williams

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

Various 1,2,5-substituted pyrroles were synthesized from 1,4-alkynediols using a ruthenium-catalyzed isomerization to give the corresponding 1,4-dicarbonyl compds., which undergo in situ cyclization to pyrroles in the presence of amine.

Original language	English
Pages (from-to)	5115-5120
Number of pages	6
Journal	Tetrahedron Letters
Volume	48
Issue number	29
Publication status	Published - 2007

Keywords

Glycols Role
Ketones Role
Heterocyclization catalysts
Isomerization
RCT (Reactant)
Isomerization catalysts (prepn. of pyrroles by ruthenium-catalyzed tandem isomerization/cyclization of alkynediols with amines)
4-
1
PREP (Preparation) (diketones
alkynediol amine tandem isomerization heterocyclization ruthenium catalyst
RACT (Reactant or reagent) (alkynyl
pyrrole prepn
RACT (Reactant or reagent) (primary
Alcohols Role
Heterocyclization
Amines Role
prepn. of pyrroles by ruthenium-catalyzed tandem isomerization/cyclization of alkynediols with amines)
RACT (Reactant or reagent) (1
SPN (Synthetic preparation)

Cite this

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title = "Ruthenium-catalyzed conversion of 1,4-alkynediols into pyrroles",

abstract = "Various 1,2,5-substituted pyrroles were synthesized from 1,4-alkynediols using a ruthenium-catalyzed isomerization to give the corresponding 1,4-dicarbonyl compds., which undergo in situ cyclization to pyrroles in the presence of amine.",

keywords = "Glycols Role, Ketones Role, Heterocyclization catalysts, Isomerization, RCT (Reactant), Isomerization catalysts (prepn. of pyrroles by ruthenium-catalyzed tandem isomerization/cyclization of alkynediols with amines), 4-, 1, PREP (Preparation) (diketones, alkynediol amine tandem isomerization heterocyclization ruthenium catalyst, RACT (Reactant or reagent) (alkynyl, pyrrole prepn, RACT (Reactant or reagent) (primary, Alcohols Role, Heterocyclization, Amines Role, prepn. of pyrroles by ruthenium-catalyzed tandem isomerization/cyclization of alkynediols with amines), RACT (Reactant or reagent) (1, SPN (Synthetic preparation)",

author = "Pridmore, {Simon J} and Slatford, {Paul A} and Aurelie Daniel and Whittlesey, {Michael K} and Williams, {Jonathan M J}",

year = "2007",

language = "English",

volume = "48",

pages = "5115--5120",

journal = "Tetrahedron Letters",

issn = "0040-4039",

publisher = "Elsevier",

number = "29",

}

TY - JOUR

T1 - Ruthenium-catalyzed conversion of 1,4-alkynediols into pyrroles

AU - Pridmore, Simon J

AU - Slatford, Paul A

AU - Daniel, Aurelie

AU - Whittlesey, Michael K

AU - Williams, Jonathan M J

PY - 2007

Y1 - 2007

N2 - Various 1,2,5-substituted pyrroles were synthesized from 1,4-alkynediols using a ruthenium-catalyzed isomerization to give the corresponding 1,4-dicarbonyl compds., which undergo in situ cyclization to pyrroles in the presence of amine.

AB - Various 1,2,5-substituted pyrroles were synthesized from 1,4-alkynediols using a ruthenium-catalyzed isomerization to give the corresponding 1,4-dicarbonyl compds., which undergo in situ cyclization to pyrroles in the presence of amine.

KW - Glycols Role

KW - Ketones Role

KW - Heterocyclization catalysts

KW - Isomerization

KW - RCT (Reactant)

KW - Isomerization catalysts (prepn. of pyrroles by ruthenium-catalyzed tandem isomerization/cyclization of alkynediols with amines)

KW - 4-

KW - 1

KW - PREP (Preparation) (diketones

KW - alkynediol amine tandem isomerization heterocyclization ruthenium catalyst

KW - RACT (Reactant or reagent) (alkynyl

KW - pyrrole prepn

KW - RACT (Reactant or reagent) (primary

KW - Alcohols Role

KW - Heterocyclization

KW - Amines Role

KW - prepn. of pyrroles by ruthenium-catalyzed tandem isomerization/cyclization of alkynediols with amines)

KW - RACT (Reactant or reagent) (1

KW - SPN (Synthetic preparation)

M3 - Article

SN - 0040-4039

VL - 48

SP - 5115

EP - 5120

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 29

ER -

Ruthenium-catalyzed conversion of 1,4-alkynediols into pyrroles

Abstract

Keywords

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