Ruthenium-catalyzed C-H functionalization of arylpyrazoles: Regioselective acylation with acid chlorides

Po Man Liu; C G Frost

doi:10.1021/ol402936c

Ruthenium-catalyzed C-H functionalization of arylpyrazoles: Regioselective acylation with acid chlorides

Po Man Liu, C G Frost

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Abstract

A ruthenium-catalyzed C-H acylation of arylpyrazoles with a variety of acyl chlorides is described. The acylation reaction exhibits good regioselectivity and both aromatic and aliphatic acyl chlorides can be effectively coupled to the arylpyrazoles at the ortho-position.

Original language	English
Pages (from-to)	5862-5865
Number of pages	4
Journal	Organic Letters
Volume	15
Issue number	22
Early online date	6 Nov 2013
DOIs	https://doi.org/10.1021/ol402936c
Publication status	Published - 15 Nov 2013

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10.1021/ol402936c

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title = "Ruthenium-catalyzed C-H functionalization of arylpyrazoles: Regioselective acylation with acid chlorides",

abstract = "A ruthenium-catalyzed C-H acylation of arylpyrazoles with a variety of acyl chlorides is described. The acylation reaction exhibits good regioselectivity and both aromatic and aliphatic acyl chlorides can be effectively coupled to the arylpyrazoles at the ortho-position. ",

author = "Liu, {Po Man} and Frost, {C G}",

year = "2013",

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AU - Liu, Po Man

AU - Frost, C G

PY - 2013/11/15

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N2 - A ruthenium-catalyzed C-H acylation of arylpyrazoles with a variety of acyl chlorides is described. The acylation reaction exhibits good regioselectivity and both aromatic and aliphatic acyl chlorides can be effectively coupled to the arylpyrazoles at the ortho-position.

AB - A ruthenium-catalyzed C-H acylation of arylpyrazoles with a variety of acyl chlorides is described. The acylation reaction exhibits good regioselectivity and both aromatic and aliphatic acyl chlorides can be effectively coupled to the arylpyrazoles at the ortho-position.

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UR - http://dx.doi.org/10.1021/ol402936c

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EP - 5865

JO - Organic Letters

JF - Organic Letters

IS - 22

ER -

Ruthenium-catalyzed C-H functionalization of arylpyrazoles: Regioselective acylation with acid chlorides

Abstract

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