Ruthenium-catalysed synthesis of tertiary amines from alcohols

M Haniti; S A Hamid; J M J Williams

doi:10.1016/j.tetlet.2007.09.134

Ruthenium-catalysed synthesis of tertiary amines from alcohols

M Haniti
, S A Hamid
, J M J Williams

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

107 Citations (SciVal)

Abstract

Secondary amines have been converted into tertiary amines by reactions with primary alcohols. A catalytic system of [Ru(cymene)Cl-2](2) with dppf has been shown to be effective for this transformation for a range of primary alcohols and secondary amines. The methodology has been applied to the one pot synthesis of Piribedil and other piperazine and morpholine-containing products. (C) 2007 Elsevier Ltd. All rights reserved.

Original language	English
Pages (from-to)	8263-8265
Number of pages	3
Journal	Tetrahedron Letters
Volume	48
Issue number	47
DOIs	https://doi.org/10.1016/j.tetlet.2007.09.134
Publication status	Published - 2007

Bibliographical note

ID number: ISI:000252097200001

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10.1016/j.tetlet.2007.09.134

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title = "Ruthenium-catalysed synthesis of tertiary amines from alcohols",

abstract = "Secondary amines have been converted into tertiary amines by reactions with primary alcohols. A catalytic system of [Ru(cymene)Cl-2](2) with dppf has been shown to be effective for this transformation for a range of primary alcohols and secondary amines. The methodology has been applied to the one pot synthesis of Piribedil and other piperazine and morpholine-containing products. (C) 2007 Elsevier Ltd. All rights reserved.",

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journal = "Tetrahedron Letters",

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AU - Haniti, M

AU - Hamid, S A

AU - Williams, J M J

N1 - ID number: ISI:000252097200001

PY - 2007

Y1 - 2007

N2 - Secondary amines have been converted into tertiary amines by reactions with primary alcohols. A catalytic system of [Ru(cymene)Cl-2](2) with dppf has been shown to be effective for this transformation for a range of primary alcohols and secondary amines. The methodology has been applied to the one pot synthesis of Piribedil and other piperazine and morpholine-containing products. (C) 2007 Elsevier Ltd. All rights reserved.

AB - Secondary amines have been converted into tertiary amines by reactions with primary alcohols. A catalytic system of [Ru(cymene)Cl-2](2) with dppf has been shown to be effective for this transformation for a range of primary alcohols and secondary amines. The methodology has been applied to the one pot synthesis of Piribedil and other piperazine and morpholine-containing products. (C) 2007 Elsevier Ltd. All rights reserved.

U2 - 10.1016/j.tetlet.2007.09.134

DO - 10.1016/j.tetlet.2007.09.134

M3 - Article

SN - 0040-4039

VL - 48

SP - 8263

EP - 8265

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 47

ER -

Ruthenium-catalysed synthesis of tertiary amines from alcohols

Abstract

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