Abstract
Secondary amines have been converted into tertiary amines by reactions with primary alcohols. A catalytic system of [Ru(cymene)Cl-2](2) with dppf has been shown to be effective for this transformation for a range of primary alcohols and secondary amines. The methodology has been applied to the one pot synthesis of Piribedil and other piperazine and morpholine-containing products. (C) 2007 Elsevier Ltd. All rights reserved.
Original language | English |
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Pages (from-to) | 8263-8265 |
Number of pages | 3 |
Journal | Tetrahedron Letters |
Volume | 48 |
Issue number | 47 |
DOIs | |
Publication status | Published - 2007 |