Ruthenium-catalysed synthesis of tertiary amines from alcohols

M Haniti, S A Hamid, J M J Williams

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Secondary amines have been converted into tertiary amines by reactions with primary alcohols. A catalytic system of [Ru(cymene)Cl-2](2) with dppf has been shown to be effective for this transformation for a range of primary alcohols and secondary amines. The methodology has been applied to the one pot synthesis of Piribedil and other piperazine and morpholine-containing products. (C) 2007 Elsevier Ltd. All rights reserved.
Original languageEnglish
Pages (from-to)8263-8265
Number of pages3
JournalTetrahedron Letters
Issue number47
Publication statusPublished - 2007

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ID number: ISI:000252097200001


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