Rudimentary signs of immunosenescence in Cytomegalovirus-seropositive healthy young adults

James E Turner; John P Campbell; Kate M Edwards; Lauren J Howarth; Graham Pawelec; Sarah Aldred; Paul Moss; Mark T Drayson; Victoria E Burns; Jos A Bosch

doi:10.1007/s11357-013-9557-4

Rudimentary signs of immunosenescence in Cytomegalovirus-seropositive healthy young adults

James E Turner, John P Campbell, Kate M Edwards, Lauren J Howarth, Graham Pawelec, Sarah Aldred, Paul Moss, Mark T Drayson, Victoria E Burns, Jos A Bosch

Department for Health

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Abstract

Ageing is associated with a decline in immune competence termed immunosenescence. In the elderly, this process results in an accumulation of differentiated 'effector' phenotype memory T cells, predominantly driven by Cytomegalovirus (CMV) infection. Here, we asked whether CMV also drives immunity towards a senescent profile in healthy young adults. One hundred and fifty-eight individuals (mean ± SD; age 21 ± 3 years, body mass index 22.7 ± 2.7 kg m(2)) were assessed for CMV serostatus, the numbers/proportions of CD4(+) and CD8(+) late differentiated/effector memory cells (i.e. CD27(-)CD28(-)/CD45RA(+)), plasma interleukin-6 (IL-6) and antibody responses to an in vivo antigen challenge (half-dose influenza vaccine). Thirty percent (48/158) of participants were CMV(+). A higher lymphocyte and CD8(+) count (both p

Original language	English
Pages (from-to)	287-297
Number of pages	11
Journal	Age
Volume	36
Issue number	1
Early online date	12 Jul 2013
DOIs	https://doi.org/10.1007/s11357-013-9557-4
Publication status	Published - 1 Feb 2014

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This is a post-peer-review, pre-copyedit version of an article published in AGE. The final authenticated version is available online at: https://doi.org/10.1007/s11357-013-9557-4
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Cite this

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title = "Rudimentary signs of immunosenescence in Cytomegalovirus-seropositive healthy young adults",

abstract = "Ageing is associated with a decline in immune competence termed immunosenescence. In the elderly, this process results in an accumulation of differentiated 'effector' phenotype memory T cells, predominantly driven by Cytomegalovirus (CMV) infection. Here, we asked whether CMV also drives immunity towards a senescent profile in healthy young adults. One hundred and fifty-eight individuals (mean ± SD; age 21 ± 3 years, body mass index 22.7 ± 2.7 kg m(2)) were assessed for CMV serostatus, the numbers/proportions of CD4(+) and CD8(+) late differentiated/effector memory cells (i.e. CD27(-)CD28(-)/CD45RA(+)), plasma interleukin-6 (IL-6) and antibody responses to an in vivo antigen challenge (half-dose influenza vaccine). Thirty percent (48/158) of participants were CMV(+). A higher lymphocyte and CD8(+) count (both p ",

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AU - Edwards, Kate M

AU - Howarth, Lauren J

AU - Pawelec, Graham

AU - Aldred, Sarah

AU - Moss, Paul

AU - Drayson, Mark T

AU - Burns, Victoria E

AU - Bosch, Jos A

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Rudimentary signs of immunosenescence in Cytomegalovirus-seropositive healthy young adults

Abstract

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