Rudimentary signs of immunosenescence in Cytomegalovirus-seropositive healthy young adults

James E Turner, John P Campbell, Kate M Edwards, Lauren J Howarth, Graham Pawelec, Sarah Aldred, Paul Moss, Mark T Drayson, Victoria E Burns, Jos A Bosch

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Abstract

Ageing is associated with a decline in immune competence termed immunosenescence. In the elderly, this process results in an accumulation of differentiated 'effector' phenotype memory T cells, predominantly driven by Cytomegalovirus (CMV) infection. Here, we asked whether CMV also drives immunity towards a senescent profile in healthy young adults. One hundred and fifty-eight individuals (mean ± SD; age 21 ± 3 years, body mass index 22.7 ± 2.7 kg m(2)) were assessed for CMV serostatus, the numbers/proportions of CD4(+) and CD8(+) late differentiated/effector memory cells (i.e. CD27(-)CD28(-)/CD45RA(+)), plasma interleukin-6 (IL-6) and antibody responses to an in vivo antigen challenge (half-dose influenza vaccine). Thirty percent (48/158) of participants were CMV(+). A higher lymphocyte and CD8(+) count (both p 
Original languageEnglish
Pages (from-to)287-297
Number of pages11
JournalAge
Volume36
Issue number1
Early online date12 Jul 2013
DOIs
Publication statusPublished - 1 Feb 2014

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    Turner, J. E., Campbell, J. P., Edwards, K. M., Howarth, L. J., Pawelec, G., Aldred, S., Moss, P., Drayson, M. T., Burns, V. E., & Bosch, J. A. (2014). Rudimentary signs of immunosenescence in Cytomegalovirus-seropositive healthy young adults. Age, 36(1), 287-297. https://doi.org/10.1007/s11357-013-9557-4