Room Temperature Regioselective Catalytic Hydrodefluorination of Fluoroarenes with trans-[Ru(NHC)4H2] Via a Converted Nucleophlic Ru-H Attack Pathway

Mateusz Cybulski, David McKay, Stuart Macgregor, Mary Mahon, Michael Whittlesey

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17 Citations (Scopus)
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Abstract

The efficient and highly selective room temperature hydrodefluorination (HDF) of fluoroarenes by the trans-[Ru(IMe4)4H2] catalyst, 3, is reported. Mechanistic studies show 3 acts directly in catalysis without any ligand dissociation and DFT calculations indicate a concerted nucleophilic attack mechanism. The calculations fully account for the observed selectivities which corroborate earlier predictions regarding the selectivity of HDF.
Original languageEnglish
Pages (from-to)1515-1519
Number of pages5
JournalAngewandte Chemie-International Edition
Volume56
Issue number6
Early online date9 Jan 2017
DOIs
Publication statusPublished - 20 Jan 2017

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