Room Temperature Regioselective Catalytic Hydrodefluorination of Fluoroarenes with trans-[Ru(NHC)4H2] Via a Converted Nucleophlic Ru-H Attack Pathway

Mateusz Cybulski, David McKay, Stuart Macgregor, Mary Mahon, Michael Whittlesey

Research output: Contribution to journalArticle

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Abstract

The efficient and highly selective room temperature hydrodefluorination (HDF) of fluoroarenes by the trans-[Ru(IMe4)4H2] catalyst, 3, is reported. Mechanistic studies show 3 acts directly in catalysis without any ligand dissociation and DFT calculations indicate a concerted nucleophilic attack mechanism. The calculations fully account for the observed selectivities which corroborate earlier predictions regarding the selectivity of HDF.
LanguageEnglish
Pages1515-1519
JournalAngewandte Chemie-International Edition
Volume56
Issue number6
Early online date9 Jan 2017
DOIs
StatusPublished - 1 Feb 2017

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Catalysis
Ligands
Temperature
dichlorotetrakis(dimethyl sulfoxide)ruthenium II

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Room Temperature Regioselective Catalytic Hydrodefluorination of Fluoroarenes with trans-[Ru(NHC)4H2] Via a Converted Nucleophlic Ru-H Attack Pathway. / Cybulski, Mateusz; McKay, David; Macgregor, Stuart; Mahon, Mary; Whittlesey, Michael.

In: Angewandte Chemie-International Edition, Vol. 56, No. 6, 01.02.2017, p. 1515-1519.

Research output: Contribution to journalArticle

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