TY - JOUR
T1 - Room-temperature gold-catalysed arylation of heteroarenes
T2 - complementarity to palladium catalysis
AU - Cresswell, Alexander J.
AU - Lloyd-Jones, Guy C.
PY - 2016/8/26
Y1 - 2016/8/26
N2 - Tailoring of the pre-catalyst, the oxidant and the arylsilane enables the first room-temperature, gold-catalysed, innate C−H arylation of heteroarenes. Regioselectivity is consistently high and, in some cases, distinct from that reported with palladium catalysis. Tolerance to halides and boronic esters, in both the heteroarene and silane partners, provides orthogonality to Suzuki–Miyaura coupling.
AB - Tailoring of the pre-catalyst, the oxidant and the arylsilane enables the first room-temperature, gold-catalysed, innate C−H arylation of heteroarenes. Regioselectivity is consistently high and, in some cases, distinct from that reported with palladium catalysis. Tolerance to halides and boronic esters, in both the heteroarene and silane partners, provides orthogonality to Suzuki–Miyaura coupling.
KW - arylation
KW - C−H functionalisation
KW - gold catalysis
KW - heteroarenes
KW - silicon
UR - http://www.scopus.com/inward/record.url?scp=84983273924&partnerID=8YFLogxK
UR - http://dx.doi.org/10.1002/chem.201602893
U2 - 10.1002/chem.201602893
DO - 10.1002/chem.201602893
M3 - Article
AN - SCOPUS:84983273924
SN - 0947-6539
VL - 22
SP - 12641
EP - 12645
JO - Chemistry - A European Journal
JF - Chemistry - A European Journal
IS - 36
ER -