Room-temperature gold-catalysed arylation of heteroarenes: complementarity to palladium catalysis

Alexander J. Cresswell, Guy C. Lloyd-Jones

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Tailoring of the pre-catalyst, the oxidant and the arylsilane enables the first room-temperature, gold-catalysed, innate C−H arylation of heteroarenes. Regioselectivity is consistently high and, in some cases, distinct from that reported with palladium catalysis. Tolerance to halides and boronic esters, in both the heteroarene and silane partners, provides orthogonality to Suzuki–Miyaura coupling.

LanguageEnglish
Pages12641-12645
Number of pages5
JournalChemistry - A European Journal
Volume22
Issue number36
DOIs
StatusPublished - 26 Aug 2016

Fingerprint

Silanes
Regioselectivity
Palladium
Oxidants
Gold
Catalysis
Esters
Catalysts
Temperature

Keywords

  • arylation
  • C−H functionalisation
  • gold catalysis
  • heteroarenes
  • silicon

Cite this

Room-temperature gold-catalysed arylation of heteroarenes : complementarity to palladium catalysis. / Cresswell, Alexander J.; Lloyd-Jones, Guy C.

In: Chemistry - A European Journal, Vol. 22, No. 36, 26.08.2016, p. 12641-12645.

Research output: Contribution to journalArticle

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