Room-temperature gold-catalysed arylation of heteroarenes: complementarity to palladium catalysis

Alexander J. Cresswell, Guy C. Lloyd-Jones

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Tailoring of the pre-catalyst, the oxidant and the arylsilane enables the first room-temperature, gold-catalysed, innate C−H arylation of heteroarenes. Regioselectivity is consistently high and, in some cases, distinct from that reported with palladium catalysis. Tolerance to halides and boronic esters, in both the heteroarene and silane partners, provides orthogonality to Suzuki–Miyaura coupling.

Original languageEnglish
Pages (from-to)12641-12645
Number of pages5
JournalChemistry - A European Journal
Issue number36
Publication statusPublished - 26 Aug 2016



  • arylation
  • C−H functionalisation
  • gold catalysis
  • heteroarenes
  • silicon

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