Risk of uveitis and inflammatory bowel disease in people with psoriatic arthritis: a population based cohort study

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Abstract

Objectives: To determine the risk of uveitis and inflammatory bowel disease (IBD) in patients with psoriatic arthritis (PsA) compared with the general population and patients with psoriasis. Methods: A cohort study using data from the UK Clinical Practice Research Datalink between 1998 and 2014. Patients with incident PsA aged 18-89 years were identified and matched to a cohort of patients with psoriasis and a general population cohort. The incidence of uveitis, all IBD, Crohn's disease and ulcerative colitis was calculated for each study cohort and adjusted relative risks (RR adj) were calculated using conditional Poisson regression. Results: 6783 incident cases of PsA were identified with a median age of 49 years. The risk of uveitis was significantly higher in the PsA cohort than in the general population and psoriasis cohorts (RR adj 3.55, 95% CI 2.21 to 5.70 and RR adj 2.13, 95% CI 1.40 to 3.24, respectively). A significant increase was observed for Crohn's disease (RR adj 2.96, 95% CI 1.46 to 6.00 and RR adj3.60, 95% CI 1.83 to 7.10) but not for ulcerative colitis (RR adj1.30, 95% CI 0.66 to 2.56 and RR adj0.98, 95% CI 0.50 to 1.92). Conclusions: I n a primary care-based incidence cohort of patients with PsA, there were substantial risks of developing uveitis and/or Crohn's disease, but not ulcerative colitis, when compared with the general population and psoriasis controls.

LanguageEnglish
Pages277-280
Number of pages4
JournalAnnals of the Rheumatic Diseases
Volume77
Issue number2
Early online date1 Nov 2017
DOIs
StatusPublished - 12 Jan 2018

ASJC Scopus subject areas

  • Rheumatology
  • Immunology and Allergy
  • Immunology
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

@article{227ce5149c6a4551ac1a2c4353dc8c3d,
title = "Risk of uveitis and inflammatory bowel disease in people with psoriatic arthritis: a population based cohort study",
abstract = "Objectives: To determine the risk of uveitis and inflammatory bowel disease (IBD) in patients with psoriatic arthritis (PsA) compared with the general population and patients with psoriasis. Methods: A cohort study using data from the UK Clinical Practice Research Datalink between 1998 and 2014. Patients with incident PsA aged 18-89 years were identified and matched to a cohort of patients with psoriasis and a general population cohort. The incidence of uveitis, all IBD, Crohn's disease and ulcerative colitis was calculated for each study cohort and adjusted relative risks (RR adj) were calculated using conditional Poisson regression. Results: 6783 incident cases of PsA were identified with a median age of 49 years. The risk of uveitis was significantly higher in the PsA cohort than in the general population and psoriasis cohorts (RR adj 3.55, 95{\%} CI 2.21 to 5.70 and RR adj 2.13, 95{\%} CI 1.40 to 3.24, respectively). A significant increase was observed for Crohn's disease (RR adj 2.96, 95{\%} CI 1.46 to 6.00 and RR adj3.60, 95{\%} CI 1.83 to 7.10) but not for ulcerative colitis (RR adj1.30, 95{\%} CI 0.66 to 2.56 and RR adj0.98, 95{\%} CI 0.50 to 1.92). Conclusions: I n a primary care-based incidence cohort of patients with PsA, there were substantial risks of developing uveitis and/or Crohn's disease, but not ulcerative colitis, when compared with the general population and psoriasis controls.",
author = "Rachel Charlton and Amelia Green and Gavin Shaddick and Julia Snowball and Alison Nightingale and William Tillett and Catherine Smith and Neil McHugh",
year = "2018",
month = "1",
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doi = "10.1136/annrheumdis-2017-212328",
language = "English",
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TY - JOUR

T1 - Risk of uveitis and inflammatory bowel disease in people with psoriatic arthritis: a population based cohort study

AU - Charlton, Rachel

AU - Green, Amelia

AU - Shaddick, Gavin

AU - Snowball, Julia

AU - Nightingale, Alison

AU - Tillett, William

AU - Smith, Catherine

AU - McHugh, Neil

PY - 2018/1/12

Y1 - 2018/1/12

N2 - Objectives: To determine the risk of uveitis and inflammatory bowel disease (IBD) in patients with psoriatic arthritis (PsA) compared with the general population and patients with psoriasis. Methods: A cohort study using data from the UK Clinical Practice Research Datalink between 1998 and 2014. Patients with incident PsA aged 18-89 years were identified and matched to a cohort of patients with psoriasis and a general population cohort. The incidence of uveitis, all IBD, Crohn's disease and ulcerative colitis was calculated for each study cohort and adjusted relative risks (RR adj) were calculated using conditional Poisson regression. Results: 6783 incident cases of PsA were identified with a median age of 49 years. The risk of uveitis was significantly higher in the PsA cohort than in the general population and psoriasis cohorts (RR adj 3.55, 95% CI 2.21 to 5.70 and RR adj 2.13, 95% CI 1.40 to 3.24, respectively). A significant increase was observed for Crohn's disease (RR adj 2.96, 95% CI 1.46 to 6.00 and RR adj3.60, 95% CI 1.83 to 7.10) but not for ulcerative colitis (RR adj1.30, 95% CI 0.66 to 2.56 and RR adj0.98, 95% CI 0.50 to 1.92). Conclusions: I n a primary care-based incidence cohort of patients with PsA, there were substantial risks of developing uveitis and/or Crohn's disease, but not ulcerative colitis, when compared with the general population and psoriasis controls.

AB - Objectives: To determine the risk of uveitis and inflammatory bowel disease (IBD) in patients with psoriatic arthritis (PsA) compared with the general population and patients with psoriasis. Methods: A cohort study using data from the UK Clinical Practice Research Datalink between 1998 and 2014. Patients with incident PsA aged 18-89 years were identified and matched to a cohort of patients with psoriasis and a general population cohort. The incidence of uveitis, all IBD, Crohn's disease and ulcerative colitis was calculated for each study cohort and adjusted relative risks (RR adj) were calculated using conditional Poisson regression. Results: 6783 incident cases of PsA were identified with a median age of 49 years. The risk of uveitis was significantly higher in the PsA cohort than in the general population and psoriasis cohorts (RR adj 3.55, 95% CI 2.21 to 5.70 and RR adj 2.13, 95% CI 1.40 to 3.24, respectively). A significant increase was observed for Crohn's disease (RR adj 2.96, 95% CI 1.46 to 6.00 and RR adj3.60, 95% CI 1.83 to 7.10) but not for ulcerative colitis (RR adj1.30, 95% CI 0.66 to 2.56 and RR adj0.98, 95% CI 0.50 to 1.92). Conclusions: I n a primary care-based incidence cohort of patients with PsA, there were substantial risks of developing uveitis and/or Crohn's disease, but not ulcerative colitis, when compared with the general population and psoriasis controls.

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DO - 10.1136/annrheumdis-2017-212328

M3 - Article

VL - 77

SP - 277

EP - 280

JO - Annals of the Rheumatic Diseases

T2 - Annals of the Rheumatic Diseases

JF - Annals of the Rheumatic Diseases

SN - 0003-4967

IS - 2

ER -