Risk of uveitis and inflammatory bowel disease in people with psoriatic arthritis: a population based cohort study

Rachel Charlton, Amelia Green, Gavin Shaddick, Julia Snowball, Alison Nightingale, William Tillett, Catherine Smith, Neil McHugh

Research output: Contribution to journalArticle

14 Citations (Scopus)
66 Downloads (Pure)

Abstract

Objectives: To determine the risk of uveitis and inflammatory bowel disease (IBD) in patients with psoriatic arthritis (PsA) compared with the general population and patients with psoriasis. Methods: A cohort study using data from the UK Clinical Practice Research Datalink between 1998 and 2014. Patients with incident PsA aged 18-89 years were identified and matched to a cohort of patients with psoriasis and a general population cohort. The incidence of uveitis, all IBD, Crohn's disease and ulcerative colitis was calculated for each study cohort and adjusted relative risks (RR adj) were calculated using conditional Poisson regression. Results: 6783 incident cases of PsA were identified with a median age of 49 years. The risk of uveitis was significantly higher in the PsA cohort than in the general population and psoriasis cohorts (RR adj 3.55, 95% CI 2.21 to 5.70 and RR adj 2.13, 95% CI 1.40 to 3.24, respectively). A significant increase was observed for Crohn's disease (RR adj 2.96, 95% CI 1.46 to 6.00 and RR adj3.60, 95% CI 1.83 to 7.10) but not for ulcerative colitis (RR adj1.30, 95% CI 0.66 to 2.56 and RR adj0.98, 95% CI 0.50 to 1.92). Conclusions: I n a primary care-based incidence cohort of patients with PsA, there were substantial risks of developing uveitis and/or Crohn's disease, but not ulcerative colitis, when compared with the general population and psoriasis controls.

Original languageEnglish
Pages (from-to)277-280
Number of pages4
JournalAnnals of the Rheumatic Diseases
Volume77
Issue number2
Early online date1 Nov 2017
DOIs
Publication statusPublished - 12 Jan 2018

ASJC Scopus subject areas

  • Rheumatology
  • Immunology and Allergy
  • Immunology
  • Biochemistry, Genetics and Molecular Biology(all)

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