Ring constrained analogues of the orvinols: The furanomorphides

Stephen M. Husbands; Simon W. Breeden; Konstantinos Grivas; John W. Lewis

doi:10.1016/S0960-894X(99)00085-2

Ring constrained analogues of the orvinols: The furanomorphides

Stephen M. Husbands, Simon W. Breeden, Konstantinos Grivas, John W. Lewis

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11 Citations (SciVal)

Abstract

A series of furanomorphides were synthesized as ring-constrained analogues of buprenorphine and related orvinols. Evaluation in binding and functional assays has shown that the furanomorphides have reduced efficacy at the υ opioid receptor compared to the orvinols.

Original language	English
Pages (from-to)	831-834
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	9
Issue number	6
DOIs	https://doi.org/10.1016/S0960-894X(99)00085-2
Publication status	Published - 22 Mar 1999

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/S0960-894X(99)00085-2

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title = "Ring constrained analogues of the orvinols: The furanomorphides",

abstract = "A series of furanomorphides were synthesized as ring-constrained analogues of buprenorphine and related orvinols. Evaluation in binding and functional assays has shown that the furanomorphides have reduced efficacy at the υ opioid receptor compared to the orvinols.",

author = "Husbands, {Stephen M.} and Breeden, {Simon W.} and Konstantinos Grivas and Lewis, {John W.}",

year = "1999",

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T2 - The furanomorphides

AU - Husbands, Stephen M.

AU - Breeden, Simon W.

AU - Grivas, Konstantinos

AU - Lewis, John W.

PY - 1999/3/22

Y1 - 1999/3/22

N2 - A series of furanomorphides were synthesized as ring-constrained analogues of buprenorphine and related orvinols. Evaluation in binding and functional assays has shown that the furanomorphides have reduced efficacy at the υ opioid receptor compared to the orvinols.

AB - A series of furanomorphides were synthesized as ring-constrained analogues of buprenorphine and related orvinols. Evaluation in binding and functional assays has shown that the furanomorphides have reduced efficacy at the υ opioid receptor compared to the orvinols.

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U2 - 10.1016/S0960-894X(99)00085-2

DO - 10.1016/S0960-894X(99)00085-2

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AN - SCOPUS:0033594155

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JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 6

ER -

Ring constrained analogues of the orvinols: The furanomorphides

Abstract

ASJC Scopus subject areas

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