Ring constrained analogues of the orvinols: The furanomorphides

Stephen M. Husbands, Simon W. Breeden, Konstantinos Grivas, John W. Lewis

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

A series of furanomorphides were synthesized as ring-constrained analogues of buprenorphine and related orvinols. Evaluation in binding and functional assays has shown that the furanomorphides have reduced efficacy at the υ opioid receptor compared to the orvinols.

Original languageEnglish
Pages (from-to)831-834
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume9
Issue number6
DOIs
Publication statusPublished - 22 Mar 1999

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

Cite this