Abstract
A series of furanomorphides were synthesized as ring-constrained analogues of buprenorphine and related orvinols. Evaluation in binding and functional assays has shown that the furanomorphides have reduced efficacy at the υ opioid receptor compared to the orvinols.
| Original language | English |
|---|---|
| Pages (from-to) | 831-834 |
| Number of pages | 4 |
| Journal | Bioorganic and Medicinal Chemistry Letters |
| Volume | 9 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - 22 Mar 1999 |
Funding
Acknowledgements: This work was supported by NIDA (OTDP Medications Development Division) grant no. DA 07315. References 1. Lewis, J.W. in Buprenorphine, Cowen, A and Lewis, J.W editors, New York, Wiley-Liss, 1995, 3-18. 2. Barton, J.W; Coop, A and Lewis, J.W. Tetrahedron Lett., 1993, 34, 6777-6778. 3. Coop. A; Grivas, K.; Husbands, S.; Lewis, J.W. and Porter J. Tetrahedron Lett., 1995, 36, 1689-1692. 4. Coop, A.; Grivas, K.; Husbands, S.; Lewis, J.W. Tetrahedron, 1995, 35, 9681-9698. 5. Coop, A.; Lewis, J.W.; Traynor, J.R. And Guo, L. N1DA Res. Monog. 1995, 153, 128. 6. Hutchins, C.W. And Rapoport, H. J. Med. Chem. 1984, 27, 521-527. 7. Bentley, K.W.; Hardy, D.G.; Meek, B.; Taylor, J.B.; Brown, J.J. And Morton, G.O.J. Chem. Soc (C), 1969, 2229-2232. 8. Grivas, K; Breeden, S.W.; Ganter, C; Husbands S.M and Lewis, J.W. Tetrahedron Lett., accepted. 9. Bentley, K.W.; Hardy, D.G. and Meek, B. J. Am. Chem. Soc., 1967, 89, 3272-3280. 10.Traynor, J.R and Nahorski, S.R. Mol. Pharmacol. 1995, 47, 848-854. 1 l.Loew, G.H and Berkowitz, D.S.J. Med. Chem., 1979, 22, 603-607.
ASJC Scopus subject areas
- Biochemistry
- Molecular Medicine
- Molecular Biology
- Pharmaceutical Science
- Drug Discovery
- Clinical Biochemistry
- Organic Chemistry