Ring constrained analogues of the orvinols: The furanomorphides

Stephen M. Husbands, Simon W. Breeden, Konstantinos Grivas, John W. Lewis

Research output: Contribution to journalArticlepeer-review

11 Citations (SciVal)


A series of furanomorphides were synthesized as ring-constrained analogues of buprenorphine and related orvinols. Evaluation in binding and functional assays has shown that the furanomorphides have reduced efficacy at the υ opioid receptor compared to the orvinols.

Original languageEnglish
Pages (from-to)831-834
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Issue number6
Publication statusPublished - 22 Mar 1999

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry


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