Rhodium-catalyzed conjugate addition-enantioselective protonation: The synthesis of alpha,alpha'-dibenzyl esters

C G Frost, S D Penrose, K Lambshead, P R Raithby, J E Warren, R GleaveO

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

alpha-Benzyl acrylates, which are conveniently prepared from the corresponding aldehydes, can be employed as substrates in a tandem rhodium-catalyzed conjugate addition-enantioselective protonation protocol to afford enantiomerically enriched alpha, alpha'-dibenzyl esters. The synergistic effect of enantiopure ligand and proton source was rapidly optimized with use of a microwave reactor.
Original languageEnglish
Pages (from-to)2119-2122
Number of pages4
JournalOrganic Letters
Volume9
Issue number11
DOIs
Publication statusPublished - 2007

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