Rhodium-catalyzed 1,4-additions to enantiopure acceptors: asymmetric synthesis of functionalized pyrrolizidinones

L Zoute, Gabriele Kociok-Kohn, Christopher G Frost

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)

Abstract

The rhodium-catalyzed 1,4-addition of arylboronic acids to an enantiopure heterocyclic acceptor proceeds under ligand control to effect an asymmetric synthesis of functionalized pyrrolizidinones. The protocol allows convenient access to all four stereoisomers of pyrrolizidinone 3a (Ar = Ph) by appropriate selection of substrate and catalyst.
Original languageEnglish
Pages (from-to)2491-2494
Number of pages4
JournalOrganic Letters
Volume11
Issue number12
Early online date21 May 2009
DOIs
Publication statusPublished - 18 Jun 2009

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