Rhodium-catalysed enantioselective synthesis of 4-arylchroman-2-ones

Joseph C Allen; Gabriele Kociok-Kohn; Christopher G Frost

doi:10.1039/c1ob06586f

Rhodium-catalysed enantioselective synthesis of 4-arylchroman-2-ones

Joseph C Allen, Gabriele Kociok-Kohn, Christopher G Frost

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Abstract

The rhodium-catalysed enantioselective 1,4-addition of organoboron reagents to arylidene Meldrum's acids as acceptors, allows convenient access to 4-arylchroman-2-ones with good to excellent levels of enantioselectivity. The use of silyl-protected dioxaborinanes as donors was found to be advantageous to achieving good yields of product under anhydrous conditions.

Original language	English
Pages (from-to)	32-35
Number of pages	4
Journal	Organic and Biomolecular Chemistry
Volume	10
Issue number	1
DOIs	https://doi.org/10.1039/c1ob06586f
Publication status	Published - 2012

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Frost_Org-Bio-Chem_2012_10_1_32.pdfAccepted author manuscript, 1.44 MB

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title = "Rhodium-catalysed enantioselective synthesis of 4-arylchroman-2-ones",

abstract = "The rhodium-catalysed enantioselective 1,4-addition of organoboron reagents to arylidene Meldrum's acids as acceptors, allows convenient access to 4-arylchroman-2-ones with good to excellent levels of enantioselectivity. The use of silyl-protected dioxaborinanes as donors was found to be advantageous to achieving good yields of product under anhydrous conditions.",

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AU - Kociok-Kohn, Gabriele

AU - Frost, Christopher G

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AB - The rhodium-catalysed enantioselective 1,4-addition of organoboron reagents to arylidene Meldrum's acids as acceptors, allows convenient access to 4-arylchroman-2-ones with good to excellent levels of enantioselectivity. The use of silyl-protected dioxaborinanes as donors was found to be advantageous to achieving good yields of product under anhydrous conditions.

UR - https://www.scopus.com/pages/publications/82955223244

UR - http://dx.doi.org/10.1039/c1ob06586f

U2 - 10.1039/c1ob06586f

DO - 10.1039/c1ob06586f

M3 - Article

SN - 1477-0520

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EP - 35

JO - Organic and Biomolecular Chemistry

JF - Organic and Biomolecular Chemistry

IS - 1

ER -

Rhodium-catalysed enantioselective synthesis of 4-arylchroman-2-ones

Abstract

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