Rhodium-catalysed enantioselective synthesis of 4-arylchroman-2-ones

Research output: Contribution to journalArticle

  • 26 Citations

Abstract

The rhodium-catalysed enantioselective 1,4-addition of organoboron reagents to arylidene Meldrum's acids as acceptors, allows convenient access to 4-arylchroman-2-ones with good to excellent levels of enantioselectivity. The use of silyl-protected dioxaborinanes as donors was found to be advantageous to achieving good yields of product under anhydrous conditions.
LanguageEnglish
Pages32-35
Number of pages4
JournalOrganic and Biomolecular Chemistry
Volume10
Issue number1
DOIs
StatusPublished - 2012

Fingerprint

Rhodium
Enantioselectivity
rhodium
reagents
acids
synthesis
products
Meldrum's acid

Cite this

Rhodium-catalysed enantioselective synthesis of 4-arylchroman-2-ones. / Allen, Joseph C; Kociok-Kohn, Gabriele; Frost, Christopher G.

In: Organic and Biomolecular Chemistry, Vol. 10, No. 1, 2012, p. 32-35.

Research output: Contribution to journalArticle

@article{e9d72003e89c404ba14e1ab5a11564ec,
title = "Rhodium-catalysed enantioselective synthesis of 4-arylchroman-2-ones",
abstract = "The rhodium-catalysed enantioselective 1,4-addition of organoboron reagents to arylidene Meldrum's acids as acceptors, allows convenient access to 4-arylchroman-2-ones with good to excellent levels of enantioselectivity. The use of silyl-protected dioxaborinanes as donors was found to be advantageous to achieving good yields of product under anhydrous conditions.",
author = "Allen, {Joseph C} and Gabriele Kociok-Kohn and Frost, {Christopher G}",
year = "2012",
doi = "10.1039/c1ob06586f",
language = "English",
volume = "10",
pages = "32--35",
journal = "Organic and Biomolecular Chemistry",
issn = "1477-0520",
publisher = "Royal Society of Chemistry",
number = "1",

}

TY - JOUR

T1 - Rhodium-catalysed enantioselective synthesis of 4-arylchroman-2-ones

AU - Allen, Joseph C

AU - Kociok-Kohn, Gabriele

AU - Frost, Christopher G

PY - 2012

Y1 - 2012

N2 - The rhodium-catalysed enantioselective 1,4-addition of organoboron reagents to arylidene Meldrum's acids as acceptors, allows convenient access to 4-arylchroman-2-ones with good to excellent levels of enantioselectivity. The use of silyl-protected dioxaborinanes as donors was found to be advantageous to achieving good yields of product under anhydrous conditions.

AB - The rhodium-catalysed enantioselective 1,4-addition of organoboron reagents to arylidene Meldrum's acids as acceptors, allows convenient access to 4-arylchroman-2-ones with good to excellent levels of enantioselectivity. The use of silyl-protected dioxaborinanes as donors was found to be advantageous to achieving good yields of product under anhydrous conditions.

UR - http://www.scopus.com/inward/record.url?scp=82955223244&partnerID=8YFLogxK

UR - http://dx.doi.org/10.1039/c1ob06586f

U2 - 10.1039/c1ob06586f

DO - 10.1039/c1ob06586f

M3 - Article

VL - 10

SP - 32

EP - 35

JO - Organic and Biomolecular Chemistry

T2 - Organic and Biomolecular Chemistry

JF - Organic and Biomolecular Chemistry

SN - 1477-0520

IS - 1

ER -