Rhodium-catalysed enantioselective synthesis of 4-arylchroman-2-ones

Joseph C Allen, Gabriele Kociok-Kohn, Christopher G Frost

Research output: Contribution to journalArticle

30 Citations (Scopus)
131 Downloads (Pure)

Abstract

The rhodium-catalysed enantioselective 1,4-addition of organoboron reagents to arylidene Meldrum's acids as acceptors, allows convenient access to 4-arylchroman-2-ones with good to excellent levels of enantioselectivity. The use of silyl-protected dioxaborinanes as donors was found to be advantageous to achieving good yields of product under anhydrous conditions.
Original languageEnglish
Pages (from-to)32-35
Number of pages4
JournalOrganic and Biomolecular Chemistry
Volume10
Issue number1
DOIs
Publication statusPublished - 2012

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