The concise enantioselective synthesis of hermitamides A and B is presented utilising a rhodium catalysed conjugate addition reaction to introduce the side chain and chiral information in a single step via an alkenyltrifluoroborate salt.
- Addition reactions
- Chemical reactions
- Aromatic hydrocarbons
Frost, C., Penrose, S., & Gleave, R. (2008). Rhodium catalysed conjugate addition of a chiral alkenyltrifluoroborate salt: The enantioselective synthesis of hermitamides A and B. Organic and Biomolecular Chemistry, 6(23), 4340-4347. https://doi.org/10.1039/b812897a