Retinoic acid signalling in neuropsychiatric disease: possible markers and treatment agents

Sarah J Bailey, P J McCaffery

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Retinoic acid is the transcriptionally active product of vitamin A, potentially controlling expression of several hundred genes through activation of specific nuclear receptors. The retinoic acid receptors (RARs) are expressed through much of the adult brain; in contrast the ligand for these receptors is much more restricted in its extent of expression. Non-liganded RARs likely control function through transcriptional repression whereas ligand activated receptors probably regulate more restricted functions including neuroplasticity and neurogenesis. Deregulation of retinoic acid signalling through application of excess levels of this ligand have been associated with depression while genetic and anatomical evidence has linked retinoic acid with the neurodevelopmental hypothesis of schizophrenia and autism. The RARs frequently act in conjunction with the second class of retinoid receptors, the retinoid X receptors (RXRs). These RXRs heterodimerize with other classes of nuclear receptors, including the thyroid hormone receptor which, like those for retinoic acid, are associated with schizophrenia and depression. It is possible that drugs that act on RXRs may be particularly effective in psychiatric disease by acting simultaneously on several nuclear receptor signalling pathways.
Original languageEnglish
Title of host publicationThe Handbook of Neuropsychiatric Biomarkers, Endophenotypes, and Genes. Volume III: Metabolic and Peripheral Biomarkers
EditorsM S Ritsner
Place of PublicationNetherlands
PublisherSpringer
Pages171-189
Number of pages19
Volume3
ISBN (Print)978-1-4020-9837-6
DOIs
Publication statusPublished - 2009

Fingerprint

Tretinoin
Retinoid X Receptors
Retinoic Acid Receptors
Cytoplasmic and Nuclear Receptors
Ligands
Schizophrenia
Depression
Thyroid Hormone Receptors
Neuronal Plasticity
Neurogenesis
Retinoids
Autistic Disorder
Vitamin A
Transcriptional Activation
Psychiatry
Brain
Pharmaceutical Preparations

Cite this

Bailey, S. J., & McCaffery, P. J. (2009). Retinoic acid signalling in neuropsychiatric disease: possible markers and treatment agents. In M. S. Ritsner (Ed.), The Handbook of Neuropsychiatric Biomarkers, Endophenotypes, and Genes. Volume III: Metabolic and Peripheral Biomarkers (Vol. 3, pp. 171-189). Netherlands: Springer. https://doi.org/10.1007/978-1-4020-9838-3_11

Retinoic acid signalling in neuropsychiatric disease: possible markers and treatment agents. / Bailey, Sarah J; McCaffery, P J.

The Handbook of Neuropsychiatric Biomarkers, Endophenotypes, and Genes. Volume III: Metabolic and Peripheral Biomarkers. ed. / M S Ritsner. Vol. 3 Netherlands : Springer, 2009. p. 171-189.

Research output: Chapter in Book/Report/Conference proceedingChapter

Bailey, SJ & McCaffery, PJ 2009, Retinoic acid signalling in neuropsychiatric disease: possible markers and treatment agents. in MS Ritsner (ed.), The Handbook of Neuropsychiatric Biomarkers, Endophenotypes, and Genes. Volume III: Metabolic and Peripheral Biomarkers. vol. 3, Springer, Netherlands, pp. 171-189. https://doi.org/10.1007/978-1-4020-9838-3_11
Bailey SJ, McCaffery PJ. Retinoic acid signalling in neuropsychiatric disease: possible markers and treatment agents. In Ritsner MS, editor, The Handbook of Neuropsychiatric Biomarkers, Endophenotypes, and Genes. Volume III: Metabolic and Peripheral Biomarkers. Vol. 3. Netherlands: Springer. 2009. p. 171-189 https://doi.org/10.1007/978-1-4020-9838-3_11
Bailey, Sarah J ; McCaffery, P J. / Retinoic acid signalling in neuropsychiatric disease: possible markers and treatment agents. The Handbook of Neuropsychiatric Biomarkers, Endophenotypes, and Genes. Volume III: Metabolic and Peripheral Biomarkers. editor / M S Ritsner. Vol. 3 Netherlands : Springer, 2009. pp. 171-189
@inbook{83fcf4e396a846c98ea94eb0b7741004,
title = "Retinoic acid signalling in neuropsychiatric disease: possible markers and treatment agents",
abstract = "Retinoic acid is the transcriptionally active product of vitamin A, potentially controlling expression of several hundred genes through activation of specific nuclear receptors. The retinoic acid receptors (RARs) are expressed through much of the adult brain; in contrast the ligand for these receptors is much more restricted in its extent of expression. Non-liganded RARs likely control function through transcriptional repression whereas ligand activated receptors probably regulate more restricted functions including neuroplasticity and neurogenesis. Deregulation of retinoic acid signalling through application of excess levels of this ligand have been associated with depression while genetic and anatomical evidence has linked retinoic acid with the neurodevelopmental hypothesis of schizophrenia and autism. The RARs frequently act in conjunction with the second class of retinoid receptors, the retinoid X receptors (RXRs). These RXRs heterodimerize with other classes of nuclear receptors, including the thyroid hormone receptor which, like those for retinoic acid, are associated with schizophrenia and depression. It is possible that drugs that act on RXRs may be particularly effective in psychiatric disease by acting simultaneously on several nuclear receptor signalling pathways.",
author = "Bailey, {Sarah J} and McCaffery, {P J}",
year = "2009",
doi = "10.1007/978-1-4020-9838-3_11",
language = "English",
isbn = "978-1-4020-9837-6",
volume = "3",
pages = "171--189",
editor = "Ritsner, {M S}",
booktitle = "The Handbook of Neuropsychiatric Biomarkers, Endophenotypes, and Genes. Volume III: Metabolic and Peripheral Biomarkers",
publisher = "Springer",

}

TY - CHAP

T1 - Retinoic acid signalling in neuropsychiatric disease: possible markers and treatment agents

AU - Bailey, Sarah J

AU - McCaffery, P J

PY - 2009

Y1 - 2009

N2 - Retinoic acid is the transcriptionally active product of vitamin A, potentially controlling expression of several hundred genes through activation of specific nuclear receptors. The retinoic acid receptors (RARs) are expressed through much of the adult brain; in contrast the ligand for these receptors is much more restricted in its extent of expression. Non-liganded RARs likely control function through transcriptional repression whereas ligand activated receptors probably regulate more restricted functions including neuroplasticity and neurogenesis. Deregulation of retinoic acid signalling through application of excess levels of this ligand have been associated with depression while genetic and anatomical evidence has linked retinoic acid with the neurodevelopmental hypothesis of schizophrenia and autism. The RARs frequently act in conjunction with the second class of retinoid receptors, the retinoid X receptors (RXRs). These RXRs heterodimerize with other classes of nuclear receptors, including the thyroid hormone receptor which, like those for retinoic acid, are associated with schizophrenia and depression. It is possible that drugs that act on RXRs may be particularly effective in psychiatric disease by acting simultaneously on several nuclear receptor signalling pathways.

AB - Retinoic acid is the transcriptionally active product of vitamin A, potentially controlling expression of several hundred genes through activation of specific nuclear receptors. The retinoic acid receptors (RARs) are expressed through much of the adult brain; in contrast the ligand for these receptors is much more restricted in its extent of expression. Non-liganded RARs likely control function through transcriptional repression whereas ligand activated receptors probably regulate more restricted functions including neuroplasticity and neurogenesis. Deregulation of retinoic acid signalling through application of excess levels of this ligand have been associated with depression while genetic and anatomical evidence has linked retinoic acid with the neurodevelopmental hypothesis of schizophrenia and autism. The RARs frequently act in conjunction with the second class of retinoid receptors, the retinoid X receptors (RXRs). These RXRs heterodimerize with other classes of nuclear receptors, including the thyroid hormone receptor which, like those for retinoic acid, are associated with schizophrenia and depression. It is possible that drugs that act on RXRs may be particularly effective in psychiatric disease by acting simultaneously on several nuclear receptor signalling pathways.

UR - http://www.springer.com/biomed/neuroscience/book/978-1-4020-9837-6

UR - http://dx.doi.org/10.1007/978-1-4020-9838-3_11

U2 - 10.1007/978-1-4020-9838-3_11

DO - 10.1007/978-1-4020-9838-3_11

M3 - Chapter

SN - 978-1-4020-9837-6

VL - 3

SP - 171

EP - 189

BT - The Handbook of Neuropsychiatric Biomarkers, Endophenotypes, and Genes. Volume III: Metabolic and Peripheral Biomarkers

A2 - Ritsner, M S

PB - Springer

CY - Netherlands

ER -