Response of monoflagellate pullers to a shearing flow: A simulation study of microswimmer guidance

Benjamin J. Walker, Kenta Ishimoto, Richard J. Wheeler, Eamonn A. Gaffney

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12 Citations (SciVal)


Microscale swimming may be intuited to be dominated by background flows, sweeping away any untethered bodies with the prevalent flow direction. However, it has been observed that many microswimmers utilize ambient flows as guidance cues, in some cases resulting in net motion upstream, contrary to the dominant background fluid direction and our accompanying intuition. Thus the hydrodynamic response of small-scale motile organisms requires careful analysis of the complex interaction between swimmer and environment. Here we investigate the effects of a Newtonian shear flow on monoflagellated swimmers with specified body symmetry, representing, for instance, the Leishmania mexicana promastigote, a parasitic hydrodynamic puller that inhabits the microenvironment of a sandfly vector midgut and is the cause of a major and neglected human tropical disease. We observe that a lack of symmetry-breaking cellular geometry results in the periodic tumbling of swimmers in the bulk, with the rotations exhibiting a linear response to changes in shearing rate enabling analytic approximation. In order to draw comparisons with the better-studied pushers, we additionally consider virtual Leishmania promastigotes in a confined but typical geometry, that of a no-slip planar solid boundary, and note that in general stable guided taxis is not exhibited amongst the range of observed behaviors. However, a repulsive boundary gives rise to significant continued taxis in the presence of shearing flow, a phenomenon that may be of particular pertinence to the infective lifecycle stage of such swimmers subject to the assumption of a Newtonian medium. We finally propose a viable and general in vitro method of controlling microswimmer boundary accumulation using temporally evolving background shear flows, based on the analysis of phase-averaged dynamics and verified in silico.

Original languageEnglish
Article number063111
JournalPhysical Review E
Issue number6
Publication statusPublished - 26 Dec 2018

Bibliographical note

Funding Information:
B.J.W. is supported by the UK Engineering and Physical Sciences Research Council (EPSRC), Grant No. EP/N509711/1. K.I. acknowledges support from a JSPS Overseas Fellowship and MEXT Leading Initiative for Excellent Young Researcher (LEADER). R.J.W. is supported by a Wellcome Trust Sir Henry Wellcome Fellowship, Grant No. 103261/Z/13/Z, and a Wellcome Trust Sir Henry Dale Fellowship, Grant No. 211075/Z/18/Z.

Publisher Copyright:
© 2018 Authors.

ASJC Scopus subject areas

  • Statistical and Nonlinear Physics
  • Statistics and Probability
  • Condensed Matter Physics


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