The piston/cylinder pair is the critical lubricating interface of axial piston pumps. It suffers from excessive wear, especially under high output pressure. The performance degradation of the piston/cylinder pair is significant to be clarified. In this paper, a wear prediction method of the piston/cylinder pair is established by coupling the load-bearing and lubrication parameters calculation model and the wear calculation model. The models are validated through experiments. The experimental and simulated results show that the wear of two ends of the cylinder bore is severe in the specific ranges of circumferential angle. The time-varying wear process of the piston/cylinder pair can be obtained by using this method; therefore, the maintenance time can be predicted.