Requirement of the agr locus for colony spreading of Staphylococcus aureus

Eleni Tsompanidou; Mark J J B Sibbald; Monika A Chlebowicz; Annette Dreisbach; Jaap Willem Back; Jan Maarten van Dijl; Girbe Buist; Emma L Denham

doi:10.1128/JB.01276-10

Requirement of the agr locus for colony spreading of Staphylococcus aureus

Eleni Tsompanidou
, Mark J J B Sibbald
, Monika A Chlebowicz
, Annette Dreisbach
, Jaap Willem Back
, Jan Maarten van Dijl
, Girbe Buist
, Emma L Denham

Department of Life Sciences

Pepscan Therapeutics
University Medical Center Groningen

Research output: Contribution to journal › Article › peer-review

61 Citations (SciVal)

Abstract

The important human pathogen Staphylococcus aureus is known to spread on soft agar plates. Here, we show that colony spreading of S. aureus involves the agr quorum-sensing system. This finding can be related to the agr-dependent expression of biosurfactants, such as phenol-soluble modulins, suggesting a connection between spreading motility and virulence.

Original language	English
Pages (from-to)	1267-72
Number of pages	6
Journal	Journal of Bacteriology
Volume	193
Issue number	5
DOIs	https://doi.org/10.1128/JB.01276-10
Publication status	Published - Mar 2011

Keywords

Bacterial Proteins/genetics
Gene Expression Regulation, Bacterial/physiology
Mutation
Quorum Sensing/physiology
Staphylococcus aureus/genetics
Surface-Active Agents/metabolism
Trans-Activators/genetics

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10.1128/JB.01276-10

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abstract = "The important human pathogen Staphylococcus aureus is known to spread on soft agar plates. Here, we show that colony spreading of S. aureus involves the agr quorum-sensing system. This finding can be related to the agr-dependent expression of biosurfactants, such as phenol-soluble modulins, suggesting a connection between spreading motility and virulence.",

keywords = "Bacterial Proteins/genetics, Gene Expression Regulation, Bacterial/physiology, Mutation, Quorum Sensing/physiology, Staphylococcus aureus/genetics, Surface-Active Agents/metabolism, Trans-Activators/genetics",

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AU - Tsompanidou, Eleni

AU - Sibbald, Mark J J B

AU - Chlebowicz, Monika A

AU - Dreisbach, Annette

AU - Back, Jaap Willem

AU - van Dijl, Jan Maarten

AU - Buist, Girbe

AU - Denham, Emma L

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KW - Bacterial Proteins/genetics

KW - Gene Expression Regulation, Bacterial/physiology

KW - Mutation

KW - Quorum Sensing/physiology

KW - Staphylococcus aureus/genetics

KW - Surface-Active Agents/metabolism

KW - Trans-Activators/genetics

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DO - 10.1128/JB.01276-10

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EP - 1272

JO - Journal of Bacteriology

JF - Journal of Bacteriology

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ER -

Requirement of the agr locus for colony spreading of Staphylococcus aureus

Abstract

Keywords

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