Requirement of the agr locus for colony spreading of Staphylococcus aureus

Eleni Tsompanidou, Mark J J B Sibbald, Monika A Chlebowicz, Annette Dreisbach, Jaap Willem Back, Jan Maarten van Dijl, Girbe Buist, Emma L Denham

Research output: Contribution to journalArticlepeer-review

54 Citations (SciVal)


The important human pathogen Staphylococcus aureus is known to spread on soft agar plates. Here, we show that colony spreading of S. aureus involves the agr quorum-sensing system. This finding can be related to the agr-dependent expression of biosurfactants, such as phenol-soluble modulins, suggesting a connection between spreading motility and virulence.

Original languageEnglish
Pages (from-to)1267-72
Number of pages6
JournalJournal of Bacteriology
Issue number5
Publication statusPublished - Mar 2011


  • Bacterial Proteins/genetics
  • Gene Expression Regulation, Bacterial/physiology
  • Mutation
  • Quorum Sensing/physiology
  • Staphylococcus aureus/genetics
  • Surface-Active Agents/metabolism
  • Trans-Activators/genetics


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