The important human pathogen Staphylococcus aureus is known to spread on soft agar plates. Here, we show that colony spreading of S. aureus involves the agr quorum-sensing system. This finding can be related to the agr-dependent expression of biosurfactants, such as phenol-soluble modulins, suggesting a connection between spreading motility and virulence.
- Bacterial Proteins/genetics
- Gene Expression Regulation, Bacterial/physiology
- Quorum Sensing/physiology
- Staphylococcus aureus/genetics
- Surface-Active Agents/metabolism