Reprogramming of liver to pancreas

Shifaan Thowfeequ; Wan-Chun Li; Jonathan M Slack; David Tosh

doi:10.1007/978-1-59745-060-7_25

Reprogramming of liver to pancreas

Shifaan Thowfeequ, Wan-Chun Li, Jonathan M Slack, David Tosh

Department of Life Sciences

Research output: Chapter or section in a book/report/conference proceeding › Book chapter

8 Citations (SciVal)

Abstract

Islet grafts have demonstrated that patients with diabetes would benefit greatly by beta-cell therapy. However, the paucity of available islets for transplantation as well as the immunological barriers faced in allogeneic transplantation represent a tremendous barrier to regenerative approaches to the treatment of diabetes. Here, we present a strategy and protocols to transdifferentiate developmentally related hepatocytes into beta-cells by the ectopic expression of critical beta-cell transcription factors.

Original language	English
Title of host publication	Stem Cells in Regenerative Medicine
Editors	J Audet, W L Stanford
Publisher	Humana Press
Pages	407-418
Number of pages	12
Edition	482
ISBN (Print)	9781588297976
DOIs	https://doi.org/10.1007/978-1-59745-060-7_25
Publication status	Published - 2009

Publication series

Name	Methods in Molecular Biology
Publisher	Humana Press

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/978-1-59745-060-7_25

Cite this

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title = "Reprogramming of liver to pancreas",

abstract = "Islet grafts have demonstrated that patients with diabetes would benefit greatly by beta-cell therapy. However, the paucity of available islets for transplantation as well as the immunological barriers faced in allogeneic transplantation represent a tremendous barrier to regenerative approaches to the treatment of diabetes. Here, we present a strategy and protocols to transdifferentiate developmentally related hepatocytes into beta-cells by the ectopic expression of critical beta-cell transcription factors.",

author = "Shifaan Thowfeequ and Wan-Chun Li and Slack, \{Jonathan M\} and David Tosh",

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AU - Thowfeequ, Shifaan

AU - Li, Wan-Chun

AU - Slack, Jonathan M

AU - Tosh, David

PY - 2009

Y1 - 2009

N2 - Islet grafts have demonstrated that patients with diabetes would benefit greatly by beta-cell therapy. However, the paucity of available islets for transplantation as well as the immunological barriers faced in allogeneic transplantation represent a tremendous barrier to regenerative approaches to the treatment of diabetes. Here, we present a strategy and protocols to transdifferentiate developmentally related hepatocytes into beta-cells by the ectopic expression of critical beta-cell transcription factors.

AB - Islet grafts have demonstrated that patients with diabetes would benefit greatly by beta-cell therapy. However, the paucity of available islets for transplantation as well as the immunological barriers faced in allogeneic transplantation represent a tremendous barrier to regenerative approaches to the treatment of diabetes. Here, we present a strategy and protocols to transdifferentiate developmentally related hepatocytes into beta-cells by the ectopic expression of critical beta-cell transcription factors.

UR - http://dx.doi.org/10.1007/978-1-59745-060-7_25

U2 - 10.1007/978-1-59745-060-7_25

DO - 10.1007/978-1-59745-060-7_25

M3 - Book chapter

SN - 9781588297976

T3 - Methods in Molecular Biology

SP - 407

EP - 418

BT - Stem Cells in Regenerative Medicine

A2 - Audet, J

A2 - Stanford, W L

PB - Humana Press

ER -

Reprogramming of liver to pancreas

Abstract

Publication series

UN SDGs

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COOPERATIVE GROUP IN ORGANOGENESIS, GROWTH AND REGENERATION

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Reprogramming of liver to pancreas

Abstract

Publication series

UN SDGs

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COOPERATIVE GROUP IN ORGANOGENESIS, GROWTH AND REGENERATION

Cite this