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Islet grafts have demonstrated that patients with diabetes would benefit greatly by beta-cell therapy. However, the paucity of available islets for transplantation as well as the immunological barriers faced in allogeneic transplantation represent a tremendous barrier to regenerative approaches to the treatment of diabetes. Here, we present a strategy and protocols to transdifferentiate developmentally related hepatocytes into beta-cells by the ectopic expression of critical beta-cell transcription factors.
|Title of host publication||Stem Cells in Regenerative Medicine|
|Editors||J Audet, W L Stanford|
|Number of pages||12|
|Publication status||Published - 2009|
|Name||Methods in Molecular Biology|