Reprogramming of liver to pancreas

Shifaan Thowfeequ, Wan-Chun Li, Jonathan M Slack, David Tosh

Research output: Chapter in Book/Report/Conference proceedingChapter

6 Citations (Scopus)

Abstract

Islet grafts have demonstrated that patients with diabetes would benefit greatly by beta-cell therapy. However, the paucity of available islets for transplantation as well as the immunological barriers faced in allogeneic transplantation represent a tremendous barrier to regenerative approaches to the treatment of diabetes. Here, we present a strategy and protocols to transdifferentiate developmentally related hepatocytes into beta-cells by the ectopic expression of critical beta-cell transcription factors.
Original languageEnglish
Title of host publicationStem Cells in Regenerative Medicine
EditorsJ Audet, W L Stanford
PublisherHumana Press
Pages407-418
Number of pages12
Edition482
ISBN (Print)9781588297976
DOIs
Publication statusPublished - 2009

Publication series

NameMethods in Molecular Biology
PublisherHumana Press

Fingerprint

Pancreas
Islets of Langerhans Transplantation
Liver
Homologous Transplantation
Cell- and Tissue-Based Therapy
Hepatocytes
Transcription Factors
Transplants
Therapeutics
Ectopic Gene Expression

Cite this

Thowfeequ, S., Li, W-C., Slack, J. M., & Tosh, D. (2009). Reprogramming of liver to pancreas. In J. Audet, & W. L. Stanford (Eds.), Stem Cells in Regenerative Medicine (482 ed., pp. 407-418). (Methods in Molecular Biology). Humana Press. https://doi.org/10.1007/978-1-59745-060-7_25

Reprogramming of liver to pancreas. / Thowfeequ, Shifaan; Li, Wan-Chun; Slack, Jonathan M; Tosh, David.

Stem Cells in Regenerative Medicine. ed. / J Audet; W L Stanford. 482. ed. Humana Press, 2009. p. 407-418 (Methods in Molecular Biology).

Research output: Chapter in Book/Report/Conference proceedingChapter

Thowfeequ, S, Li, W-C, Slack, JM & Tosh, D 2009, Reprogramming of liver to pancreas. in J Audet & WL Stanford (eds), Stem Cells in Regenerative Medicine. 482 edn, Methods in Molecular Biology, Humana Press, pp. 407-418. https://doi.org/10.1007/978-1-59745-060-7_25
Thowfeequ S, Li W-C, Slack JM, Tosh D. Reprogramming of liver to pancreas. In Audet J, Stanford WL, editors, Stem Cells in Regenerative Medicine. 482 ed. Humana Press. 2009. p. 407-418. (Methods in Molecular Biology). https://doi.org/10.1007/978-1-59745-060-7_25
Thowfeequ, Shifaan ; Li, Wan-Chun ; Slack, Jonathan M ; Tosh, David. / Reprogramming of liver to pancreas. Stem Cells in Regenerative Medicine. editor / J Audet ; W L Stanford. 482. ed. Humana Press, 2009. pp. 407-418 (Methods in Molecular Biology).
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