Reprogramming of liver to pancreas

Shifaan Thowfeequ, Wan-Chun Li, Jonathan M Slack, David Tosh

Research output: Chapter in Book/Report/Conference proceedingChapter

7 Citations (Scopus)

Abstract

Islet grafts have demonstrated that patients with diabetes would benefit greatly by beta-cell therapy. However, the paucity of available islets for transplantation as well as the immunological barriers faced in allogeneic transplantation represent a tremendous barrier to regenerative approaches to the treatment of diabetes. Here, we present a strategy and protocols to transdifferentiate developmentally related hepatocytes into beta-cells by the ectopic expression of critical beta-cell transcription factors.
Original languageEnglish
Title of host publicationStem Cells in Regenerative Medicine
EditorsJ Audet, W L Stanford
PublisherHumana Press
Pages407-418
Number of pages12
Edition482
ISBN (Print)9781588297976
DOIs
Publication statusPublished - 2009

Publication series

NameMethods in Molecular Biology
PublisherHumana Press

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    Thowfeequ, S., Li, W-C., Slack, J. M., & Tosh, D. (2009). Reprogramming of liver to pancreas. In J. Audet, & W. L. Stanford (Eds.), Stem Cells in Regenerative Medicine (482 ed., pp. 407-418). (Methods in Molecular Biology). Humana Press. https://doi.org/10.1007/978-1-59745-060-7_25