Reprogramming of liver to pancreas

Shifaan Thowfeequ; Wan-Chun Li; Jonathan M Slack; David Tosh

doi:10.1007/978-1-59745-060-7_25

Reprogramming of liver to pancreas

Shifaan Thowfeequ, Wan-Chun Li, Jonathan M Slack, David Tosh

Department of Life Sciences

Research output: Chapter or section in a book/report/conference proceeding › Chapter or section

8 Citations (SciVal)

Abstract

Islet grafts have demonstrated that patients with diabetes would benefit greatly by beta-cell therapy. However, the paucity of available islets for transplantation as well as the immunological barriers faced in allogeneic transplantation represent a tremendous barrier to regenerative approaches to the treatment of diabetes. Here, we present a strategy and protocols to transdifferentiate developmentally related hepatocytes into beta-cells by the ectopic expression of critical beta-cell transcription factors.

Original language	English
Title of host publication	Stem Cells in Regenerative Medicine
Editors	J Audet, W L Stanford
Publisher	Humana Press
Pages	407-418
Number of pages	12
Edition	482
ISBN (Print)	9781588297976
DOIs	https://doi.org/10.1007/978-1-59745-060-7_25
Publication status	Published - 2009

Publication series

Name	Methods in Molecular Biology
Publisher	Humana Press

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1007/978-1-59745-060-7_25

Cite this

@inbook{a81f87365fdc46c2ab4bd3ec666ea8df,

title = "Reprogramming of liver to pancreas",

abstract = "Islet grafts have demonstrated that patients with diabetes would benefit greatly by beta-cell therapy. However, the paucity of available islets for transplantation as well as the immunological barriers faced in allogeneic transplantation represent a tremendous barrier to regenerative approaches to the treatment of diabetes. Here, we present a strategy and protocols to transdifferentiate developmentally related hepatocytes into beta-cells by the ectopic expression of critical beta-cell transcription factors.",

author = "Shifaan Thowfeequ and Wan-Chun Li and Slack, {Jonathan M} and David Tosh",

year = "2009",

doi = "10.1007/978-1-59745-060-7_25",

language = "English",

isbn = "9781588297976",

series = "Methods in Molecular Biology",

publisher = "Humana Press",

pages = "407--418",

editor = "J Audet and Stanford, {W L}",

booktitle = "Stem Cells in Regenerative Medicine",

address = "USA United States",

edition = "482",

}

TY - CHAP

T1 - Reprogramming of liver to pancreas

AU - Thowfeequ, Shifaan

AU - Li, Wan-Chun

AU - Slack, Jonathan M

AU - Tosh, David

PY - 2009

Y1 - 2009

N2 - Islet grafts have demonstrated that patients with diabetes would benefit greatly by beta-cell therapy. However, the paucity of available islets for transplantation as well as the immunological barriers faced in allogeneic transplantation represent a tremendous barrier to regenerative approaches to the treatment of diabetes. Here, we present a strategy and protocols to transdifferentiate developmentally related hepatocytes into beta-cells by the ectopic expression of critical beta-cell transcription factors.

AB - Islet grafts have demonstrated that patients with diabetes would benefit greatly by beta-cell therapy. However, the paucity of available islets for transplantation as well as the immunological barriers faced in allogeneic transplantation represent a tremendous barrier to regenerative approaches to the treatment of diabetes. Here, we present a strategy and protocols to transdifferentiate developmentally related hepatocytes into beta-cells by the ectopic expression of critical beta-cell transcription factors.

UR - http://dx.doi.org/10.1007/978-1-59745-060-7_25

U2 - 10.1007/978-1-59745-060-7_25

DO - 10.1007/978-1-59745-060-7_25

M3 - Chapter or section

SN - 9781588297976

T3 - Methods in Molecular Biology

SP - 407

EP - 418

BT - Stem Cells in Regenerative Medicine

A2 - Audet, J

A2 - Stanford, W L

PB - Humana Press

ER -

Reprogramming of liver to pancreas

Abstract

Publication series

UN SDGs

Access to Document

Other files and links

Fingerprint

COOPERATIVE GROUP IN ORGANOGENESIS, GROWTH AND REGENERATION

Cite this

Reprogramming of liver to pancreas

Abstract

Publication series

UN SDGs

Access to Document

Other files and links

Fingerprint

Projects

COOPERATIVE GROUP IN ORGANOGENESIS, GROWTH AND REGENERATION

Cite this