Repeated confidence intervals for the median survival time

Christopher Jennison, Bruce W. Turnbull

Research output: Contribution to journalArticlepeer-review


We describe methods for the construction of a confidence interval for median survival time based on right-censored data. These methods are extended to the construction of repeated confidence intervals for the median, based on accumulating data; here, the overall probability that all intervals contain the true median is guaranteed at a fixed level. The use of repeated confidence intervals for median survival time in post-marketing surveillance is discussed.

Original languageEnglish
Pages (from-to)619-625
Number of pages7
Issue number3
Publication statusPublished - 1 Dec 1985

Bibliographical note

Funding Information:
The authors are grateful to Eric Slud for the martingale method of proof of the asymptotic results given in the Appendix. The authors' research was supported by a grant from the National Institutes of Health.

Copyright 2010 Elsevier B.V., All rights reserved.


  • Censored data
  • Confidence interval
  • Group sequential test
  • Interim analysis
  • Kaplan Meier estimator
  • Median survival time
  • Phase IV clinical trial

ASJC Scopus subject areas

  • Statistics and Probability
  • Mathematics(all)
  • Agricultural and Biological Sciences (miscellaneous)
  • Agricultural and Biological Sciences(all)
  • Statistics, Probability and Uncertainty
  • Applied Mathematics


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