Abstract
We describe methods for the construction of a confidence interval for median survival time based on right-censored data. These methods are extended to the construction of repeated confidence intervals for the median, based on accumulating data; here, the overall probability that all intervals contain the true median is guaranteed at a fixed level. The use of repeated confidence intervals for median survival time in post-marketing surveillance is discussed.
| Original language | English |
|---|---|
| Pages (from-to) | 619-625 |
| Number of pages | 7 |
| Journal | Biometrika |
| Volume | 72 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 1 Dec 1985 |
Keywords
- Censored data
- Confidence interval
- Group sequential test
- Interim analysis
- Kaplan Meier estimator
- Median survival time
- Phase IV clinical trial
ASJC Scopus subject areas
- Statistics and Probability
- Mathematics(all)
- Agricultural and Biological Sciences (miscellaneous)
- Agricultural and Biological Sciences(all)
- Statistics, Probability and Uncertainty
- Applied Mathematics