Abstract
The Ireland - Claisen [3,3]-sigmatropic rearrangement has been used to access biologically important β,β′-dihydroxy α-amino acids. The rearrangement reported is highly stereoselective and offers excellent levels of remote stereocontrol. This strategy has been used to synthesize the natural immunosuppressant mycestericin G and ent-mycestericin G, allowing for a revision of absolute configuration of this natural product.
Original language | English |
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Pages (from-to) | 756-759 |
Number of pages | 4 |
Journal | Organic Letters |
Volume | 14 |
Issue number | 3 |
Early online date | 12 Jan 2012 |
DOIs | |
Publication status | Published - 3 Feb 2012 |