Relationship of PKA and acute skin irritation in humans

Bret Berner; Donald R. Wilson; Richard H. Guy; Gerard C. Mazzenga; Frank H. Clarke; Howard I. Maibach

doi:10.3109/15569528909062952

Relationship of PKA and acute skin irritation in humans

Bret Berner, Donald R. Wilson, Richard H. Guy, Gerard C. Mazzenga, Frank H. Clarke, Howard I. Maibach

Research output: Contribution to journal › Article › peer-review

Abstract

The relationship between pKa and skin irritation in humans was studied for a homologous series of benzoic acid derivatives with predicted permeation through human skin at comparable rates (15-90 μg/cm²/hr). Skin irritation and pKa are strongly correlated, and, for pKa ≤4, skin irritation rapidly increases. Laser Doppler velocimetric assessment of skin blood flow, color meter readings, erythema, edema, and the primary irritation index are all linearly correlated and related to pKa; erythema at 24 hr appears to be the most sensitive variable.

Original language	English
Pages (from-to)	481-492
Number of pages	12
Journal	Cutaneous and Ocular Toxicology
Volume	8
Issue number	4
DOIs	https://doi.org/10.3109/15569528909062952
Publication status	Published - 31 Dec 1989

Bibliographical note

Funding Information:
RHG is the recipient of a special Emphasis Research Career Award (KOl-OH-00017) from the National Institute of Occupational Safety and Health. He is supported in part by NIH Grant GM-33395.

Funding

RHG is the recipient of a special Emphasis Research Career Award (KOl-OH-00017) from the National Institute of Occupational Safety and Health. He is supported in part by NIH Grant GM-33395.

ASJC Scopus subject areas

Toxicology

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10.3109/15569528909062952

Cite this

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title = "Relationship of PKA and acute skin irritation in humans",

abstract = "The relationship between pKa and skin irritation in humans was studied for a homologous series of benzoic acid derivatives with predicted permeation through human skin at comparable rates (15-90 μg/cm2/hr). Skin irritation and pKa are strongly correlated, and, for pKa ≤4, skin irritation rapidly increases. Laser Doppler velocimetric assessment of skin blood flow, color meter readings, erythema, edema, and the primary irritation index are all linearly correlated and related to pKa; erythema at 24 hr appears to be the most sensitive variable.",

author = "Bret Berner and Wilson, \{Donald R.\} and Guy, \{Richard H.\} and Mazzenga, \{Gerard C.\} and Clarke, \{Frank H.\} and Maibach, \{Howard I.\}",

note = "Funding Information: RHG is the recipient of a special Emphasis Research Career Award (KOl-OH-00017) from the National Institute of Occupational Safety and Health. He is supported in part by NIH Grant GM-33395.",

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doi = "10.3109/15569528909062952",

language = "English",

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AU - Berner, Bret

AU - Wilson, Donald R.

AU - Guy, Richard H.

AU - Mazzenga, Gerard C.

AU - Clarke, Frank H.

AU - Maibach, Howard I.

N1 - Funding Information: RHG is the recipient of a special Emphasis Research Career Award (KOl-OH-00017) from the National Institute of Occupational Safety and Health. He is supported in part by NIH Grant GM-33395.

PY - 1989/12/31

Y1 - 1989/12/31

N2 - The relationship between pKa and skin irritation in humans was studied for a homologous series of benzoic acid derivatives with predicted permeation through human skin at comparable rates (15-90 μg/cm2/hr). Skin irritation and pKa are strongly correlated, and, for pKa ≤4, skin irritation rapidly increases. Laser Doppler velocimetric assessment of skin blood flow, color meter readings, erythema, edema, and the primary irritation index are all linearly correlated and related to pKa; erythema at 24 hr appears to be the most sensitive variable.

AB - The relationship between pKa and skin irritation in humans was studied for a homologous series of benzoic acid derivatives with predicted permeation through human skin at comparable rates (15-90 μg/cm2/hr). Skin irritation and pKa are strongly correlated, and, for pKa ≤4, skin irritation rapidly increases. Laser Doppler velocimetric assessment of skin blood flow, color meter readings, erythema, edema, and the primary irritation index are all linearly correlated and related to pKa; erythema at 24 hr appears to be the most sensitive variable.

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ER -

Relationship of PKA and acute skin irritation in humans

Abstract

Bibliographical note

Funding

ASJC Scopus subject areas

Access to Document

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