Relationship of PKA and acute skin irritation in humans

Bret Berner, Donald R. Wilson, Richard H. Guy, Gerard C. Mazzenga, Frank H. Clarke, Howard I. Maibach

Research output: Contribution to journalArticlepeer-review


The relationship between pKa and skin irritation in humans was studied for a homologous series of benzoic acid derivatives with predicted permeation through human skin at comparable rates (15-90 μg/cm2/hr). Skin irritation and pKa are strongly correlated, and, for pKa ≤4, skin irritation rapidly increases. Laser Doppler velocimetric assessment of skin blood flow, color meter readings, erythema, edema, and the primary irritation index are all linearly correlated and related to pKa; erythema at 24 hr appears to be the most sensitive variable.

Original languageEnglish
Pages (from-to)481-492
Number of pages12
JournalCutaneous and Ocular Toxicology
Issue number4
Publication statusPublished - 31 Dec 1989

ASJC Scopus subject areas

  • Toxicology


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