Regulation of VSMC behavior by the cadherin-catenin complex

Cressida Lyon, Carina Mill, Aikaterini Tsaousi, Helen Williams, Sarah George

Research output: Contribution to journalReview article

20 Citations (Scopus)

Abstract

Vascular smooth muscle cells (VSMCs) are the predominant cell type within blood vessels. In normal vessels VSMC have low rates of proliferation, migration and apoptosis. However, increased VSMC proliferation, migration, and apoptosis rates radically alter the composition and structure of the blood vessel wall and contribute to vascular diseases such as atherosclerosis, in-stent restenosis and vein graft failure. Consequently, therapies that modulate VSMC proliferation, migration and apoptosis may be useful for treating vascular diseases. In this review article we discuss recently emerging research that has revealed that homophilic cell-cell contacts mediated by the cadherin:catenin complex and Wnt/beta-catenin signalling are important regulators of VSMC behaviour.

Original languageEnglish
Pages (from-to)644-57
Number of pages14
JournalFrontiers in Bioscience
Volume16
DOIs
Publication statusPublished - 1 Jan 2011

Keywords

  • Animals
  • Apoptosis/physiology
  • Atherosclerosis/drug therapy
  • Cadherins/physiology
  • Catenins
  • Cell Movement/physiology
  • Cell Proliferation/drug effects
  • Humans
  • Muscle, Smooth, Vascular/cytology
  • Plaque, Atherosclerotic/etiology
  • Signal Transduction/physiology
  • Wnt Proteins/physiology
  • beta Catenin/physiology

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