Regulation of the Wilms' tumour suppressor (WT1) gene by an antisense RNA: a link with genomic imprinting?

A Ward, J R Dutton

Research output: Contribution to journalReview article

8 Citations (Scopus)

Abstract

Antisense transcripts are typically associated with the down-regulation of gene expression. In this issue, Moorwood et al. present evidence that an antisense RNA can enhance expression of the Wilms' tumour suppressor locus WT1. We suggest that the unusual function of the WT1 antisense RNA might relate to the recent discovery of an antisense transcript that is involved in regulating imprinted expression of the murine Igf2r gene, particularly since there is some evidence that the WT1 gene is regulated by genomic imprinting in humans.

LanguageEnglish
Pages342-344
Number of pages3
JournalThe Journal of Pathology
Volume185
Issue number4
DOIs
StatusPublished - Aug 1998

Fingerprint

Wilms' Tumor Genes
Genomic Imprinting
Antisense RNA
Tumor Suppressor Genes
Wilms Tumor
Gene Expression Regulation
Genes
Down-Regulation

Keywords

  • Animals
  • Gene Expression Regulation, Neoplastic
  • Genes, Wilms Tumor
  • Genomic Imprinting
  • Humans
  • Mice
  • RNA, Antisense
  • Receptor, IGF Type 2
  • Editorial

Cite this

Regulation of the Wilms' tumour suppressor (WT1) gene by an antisense RNA : a link with genomic imprinting? / Ward, A; Dutton, J R.

In: The Journal of Pathology, Vol. 185, No. 4, 08.1998, p. 342-344.

Research output: Contribution to journalReview article

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