Regulation of the intestinal epithelial paracellular barrier

Ann L. Daugherty, Randall J. Mrsny

Research output: Contribution to journalReview articlepeer-review

57 Citations (SciVal)

Abstract

Paracellular transport of orally-administered drugs, the passage of molecules between adjacent intestinal epithelial cells, is impeded by a range of structural and functional features found in the intestine. An increased knowledge of the mechanisms that govern the paracellular barrier will enable the pharmaceutical scientist to design novel and rational formulations and delivery platforms that will improve the oral bioavailability of therapeutic molecules, particularly proteins and peptides, which would be taken-up by the paracellular pathway.

Original languageEnglish
Pages (from-to)281-287
Number of pages7
JournalPharmaceutical Science and Technology Today
Volume2
Issue number7
DOIs
Publication statusPublished - 1 Jul 1999

ASJC Scopus subject areas

  • Pharmaceutical Science

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