Regioselective Transition-Metal-Catalyzed C–H Functionalization of Anilines

Jamie A. Leitch, Christopher G. Frost

Research output: Contribution to journalReview articlepeer-review

21 Citations (SciVal)
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Anilines are a vital synthetic core of pharmaceuticals, agrochemicals, natural products and building blocks. Metal-catalyzed C–H functionalization has emerged as a powerful tool to derivatize biologically relevant molecules. To this end, the derivation of anilines via catalytic C–H functionalization has been the subject of important new synthetic methodology. This review focuses on the tactics used to allow regioselective C–H functionalization of anilines. 1 Introduction 2 ortho -Selective C–H Functionalization 2.1 Palladium 2.2 Rhodium 2.3 Ruthenium 2.4 Nickel 3 meta -Selective C–H Functionalization 4 para -Selective C–H Functionalization 5 Conclusion

Original languageEnglish
Pages (from-to)2693-2706
Number of pages14
JournalSynthesis (Germany)
Issue number14
Early online date11 Jun 2018
Publication statusPublished - 17 Jul 2018


  • anilines
  • aromatic
  • C–H functionalization
  • homogeneous catalysis
  • regioselectivity

ASJC Scopus subject areas

  • Catalysis
  • Organic Chemistry


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