TY - JOUR
T1 - Reducing Valence States of Co Active Sites in a Single-Atom Nanozyme for Boosted Tumor Therapy
AU - Wang, Hui
AU - Wang, Yan
AU - Lu, Lilin
AU - Ma, Qian
AU - Feng, Ruxin
AU - Xu, Suying
AU - James, Tony D.
AU - Wang, Leyu
N1 - Funding Information:
This research was supported in part by the National Natural Science Foundation of China (21725501 and 21874007), Beijing Municipal Natural Science Foundation (2212011), and the Fundamental Research Funds for the Central Universities (PY2101 and XK1901). T.D.J. wishes to thank the Royal Society for a Wolfson Research Merit Award and the Open Research Fund of the School of Chemistry and Chemical Engineering, Henan Normal University for support (2020ZD01).
PY - 2022/7/11
Y1 - 2022/7/11
N2 - The construction of biocompatible and trackable-imaging single-atom nanozymes (SAzymes) with efficient catalytic activities is particularly desirable. Here, cobalt/titanium oxide (Co/TiO2) SAzymes are presented with cobalt atomically dispersed on nanoporous hollow TiO2 using a cation-exchange strategy. Significantly, by varying the calcination conditions, the enzyme-like activity can be enhanced tenfold. It is determined that different calcination treatments result in valence state shifts of the Co active site due to changes in the amounts of defects, which affects the catalytic kinetics. Moreover, Co/TiO2 SAzymes exhibit good intrinsic biocompatibility and excellent tolerance toward the biological medium, while the hollow structure facilitates the loading of drugs and imaging agents for image-guided chemo-chemodynamic therapy via intravenous injection. This study not only provides a paradigm shift for the preparation of biocompatible SAzymes but also presents new insights for modulating the catalytic activity of SAzymes.
AB - The construction of biocompatible and trackable-imaging single-atom nanozymes (SAzymes) with efficient catalytic activities is particularly desirable. Here, cobalt/titanium oxide (Co/TiO2) SAzymes are presented with cobalt atomically dispersed on nanoporous hollow TiO2 using a cation-exchange strategy. Significantly, by varying the calcination conditions, the enzyme-like activity can be enhanced tenfold. It is determined that different calcination treatments result in valence state shifts of the Co active site due to changes in the amounts of defects, which affects the catalytic kinetics. Moreover, Co/TiO2 SAzymes exhibit good intrinsic biocompatibility and excellent tolerance toward the biological medium, while the hollow structure facilitates the loading of drugs and imaging agents for image-guided chemo-chemodynamic therapy via intravenous injection. This study not only provides a paradigm shift for the preparation of biocompatible SAzymes but also presents new insights for modulating the catalytic activity of SAzymes.
KW - F magnetic resonance imaging
KW - cation-exchange strategy
KW - charge regulation
KW - chemodynamic therapy
KW - single-atom nanozyme
UR - http://www.scopus.com/inward/record.url?scp=85128028821&partnerID=8YFLogxK
U2 - 10.1002/adfm.202200331
DO - 10.1002/adfm.202200331
M3 - Article
AN - SCOPUS:85128028821
VL - 32
JO - Advanced Functional Materials
JF - Advanced Functional Materials
SN - 1616-301X
IS - 28
M1 - 2200331
ER -