Recovery of human skin impedance in vivo after iontophoresis: effect of metal ions

Catherine Curdy, Yogeshvar N. Kalia, Françoise Falson-Rieg, Richard H. Guy

Research output: Contribution to journalArticlepeer-review

Abstract

The objective of this study was to investigate the effect of the counter-ion (cation) on the recovery of human skin impedance after iontophoresis in vivo. A series of metal chloride aqueous solutions (NaCl, KCl, CaCl2, and MgCl2) was investigated: first at the same concentration (133 mmol/L) and then at the same ionic strength as a NaCl solution at 133 mmol/L. The influence of hydration alone was also examined as a control. The recovery of human skin impedance was followed in the frequency range 1-1,000 Hz, over a 30-minute period after iontophoresis during which 3 impedance spectra were recorded. The results revealed that at t = 30 minutes post-iontophoresis, skin impedance was approximately 3 times greater than the value immediately after the cessation of current passage. However, the results showed that the nature of the cation had no effect on recovery, regardless of whether the ions were at the same concentration or at an equivalent ionic strength. A simple parallel RCequivalent circuit model for skin was used to determine the resistive (R) and capacitive (C) contributions to skin impedance. An analysis of variance on the calculated R and C values did not show any differences between the electrolytes used at the 2 different ionic strengths.

Original languageEnglish
Article number23
Number of pages7
JournalAAPS Journal
Volume2
Issue number3
Publication statusPublished - 2000

ASJC Scopus subject areas

  • Pharmaceutical Science

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