Reconciling diverse mammalian pigmentation patterns with a fundamental mathematical model

Richard L. Mort, Robert J. H. Ross, Kirsten J. Hainey, Olivia J. Harrison, Margaret A. Keighren, Gabriel Landini, Ruth E. Baker, Kevin J. Painter, Ian J. Jackson, Christian A. Yates

Research output: Contribution to journalArticle

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Abstract

Bands of colour extending laterally from the dorsal to ventral trunk are a common feature of mouse chimeras. These stripes were originally taken as evidence of the directed dorsoventral migration of melanoblasts (the embryonic precursors of melanocytes) as they colonize the developing skin. Depigmented ‘belly spots’ in mice with mutations in the receptor tyrosine kinase Kit are thought to represent a failure of this colonization, either due to impaired migration or proliferation. Tracing of single melanoblast clones, however, has revealed a diffuse distribution with high levels of axial mixing—hard to reconcile with directed migration. Here we construct an agent-based stochastic model calibrated by experimental measurements to investigate the formation of diffuse clones, chimeric stripes and belly spots. Our observations indicate that melanoblast colonization likely proceeds through a process of undirected migration, proliferation and tissue expansion, and that reduced proliferation is the cause of the belly spots in Kit mutants.
Original languageEnglish
Article number10288
Pages (from-to)1-13
Number of pages13
JournalNature Communications
Volume7
DOIs
Publication statusPublished - 6 Jan 2016

Fingerprint

Pigmentation
Receptor Protein-Tyrosine Kinases
Stochastic models
mathematical models
Skin
Theoretical Models
Clone Cells
Tissue
Mathematical models
Tissue Expansion
Color
kits
Melanocytes
mice
Mutation
tyrosine
mutations
tracing
color
expansion

Keywords

  • Cell migration
  • Pigment Patterns
  • mathematical modelling
  • Mathematical BIology
  • Computational modelling
  • Piebaldism

Cite this

Mort, R. L., Ross, R. J. H., Hainey, K. J., Harrison, O. J., Keighren, M. A., Landini, G., ... Yates, C. A. (2016). Reconciling diverse mammalian pigmentation patterns with a fundamental mathematical model. Nature Communications, 7, 1-13. [10288]. https://doi.org/10.1038/ncomms10288

Reconciling diverse mammalian pigmentation patterns with a fundamental mathematical model. / Mort, Richard L.; Ross, Robert J. H.; Hainey, Kirsten J.; Harrison, Olivia J.; Keighren, Margaret A.; Landini, Gabriel; Baker, Ruth E.; Painter, Kevin J.; Jackson, Ian J.; Yates, Christian A.

In: Nature Communications, Vol. 7, 10288, 06.01.2016, p. 1-13.

Research output: Contribution to journalArticle

Mort, RL, Ross, RJH, Hainey, KJ, Harrison, OJ, Keighren, MA, Landini, G, Baker, RE, Painter, KJ, Jackson, IJ & Yates, CA 2016, 'Reconciling diverse mammalian pigmentation patterns with a fundamental mathematical model', Nature Communications, vol. 7, 10288, pp. 1-13. https://doi.org/10.1038/ncomms10288
Mort RL, Ross RJH, Hainey KJ, Harrison OJ, Keighren MA, Landini G et al. Reconciling diverse mammalian pigmentation patterns with a fundamental mathematical model. Nature Communications. 2016 Jan 6;7:1-13. 10288. https://doi.org/10.1038/ncomms10288
Mort, Richard L. ; Ross, Robert J. H. ; Hainey, Kirsten J. ; Harrison, Olivia J. ; Keighren, Margaret A. ; Landini, Gabriel ; Baker, Ruth E. ; Painter, Kevin J. ; Jackson, Ian J. ; Yates, Christian A. / Reconciling diverse mammalian pigmentation patterns with a fundamental mathematical model. In: Nature Communications. 2016 ; Vol. 7. pp. 1-13.
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