Receptor-mediated elevation of adenylate cyclase by luteinizing hormone in Candida albicans

Robert J Williams; K Dickinson; O S Kinsman; T A Bramley; G S Menzies; D J Adams

doi:10.1099/00221287-136-11-2143

Receptor-mediated elevation of adenylate cyclase by luteinizing hormone in Candida albicans

Robert J Williams, K Dickinson, O S Kinsman, T A Bramley, G S Menzies, D J Adams

Department of Life Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

Human luteinizing hormone (hLH) and the GTP analogue guanosine 5'-O-(3-thio)triphosphate stimulated morphogenesis in the dimorphic fungal pathogen Candida albicans. hLH bound specifically to subcellular fractions from C. albicans and stimulated adenylate cyclase activity in C. albicans microsomes. We provide the first demonstration of guanine-nucleotide-binding proteins (G-proteins) in C. albicans, and propose that the stimulation of C. albicans morphogenesis by hLH is mediated by a receptor-coupled adenylate cyclase system involving G-proteins.

Original language	English
Pages (from-to)	2143-2148
Number of pages	6
Journal	Journal of General Microbiology
Volume	136
Issue number	11
DOIs	https://doi.org/10.1099/00221287-136-11-2143
Publication status	Published - 1990

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title = "Receptor-mediated elevation of adenylate cyclase by luteinizing hormone in Candida albicans",

abstract = "Human luteinizing hormone (hLH) and the GTP analogue guanosine 5'-O-(3-thio)triphosphate stimulated morphogenesis in the dimorphic fungal pathogen Candida albicans. hLH bound specifically to subcellular fractions from C. albicans and stimulated adenylate cyclase activity in C. albicans microsomes. We provide the first demonstration of guanine-nucleotide-binding proteins (G-proteins) in C. albicans, and propose that the stimulation of C. albicans morphogenesis by hLH is mediated by a receptor-coupled adenylate cyclase system involving G-proteins.",

author = "Williams, {Robert J} and K Dickinson and Kinsman, {O S} and Bramley, {T A} and Menzies, {G S} and Adams, {D J}",

year = "1990",

doi = "10.1099/00221287-136-11-2143",

language = "English",

volume = "136",

pages = "2143--2148",

journal = "Journal of General Microbiology",

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T1 - Receptor-mediated elevation of adenylate cyclase by luteinizing hormone in Candida albicans

AU - Williams, Robert J

AU - Dickinson, K

AU - Kinsman, O S

AU - Bramley, T A

AU - Menzies, G S

AU - Adams, D J

PY - 1990

Y1 - 1990

N2 - Human luteinizing hormone (hLH) and the GTP analogue guanosine 5'-O-(3-thio)triphosphate stimulated morphogenesis in the dimorphic fungal pathogen Candida albicans. hLH bound specifically to subcellular fractions from C. albicans and stimulated adenylate cyclase activity in C. albicans microsomes. We provide the first demonstration of guanine-nucleotide-binding proteins (G-proteins) in C. albicans, and propose that the stimulation of C. albicans morphogenesis by hLH is mediated by a receptor-coupled adenylate cyclase system involving G-proteins.

AB - Human luteinizing hormone (hLH) and the GTP analogue guanosine 5'-O-(3-thio)triphosphate stimulated morphogenesis in the dimorphic fungal pathogen Candida albicans. hLH bound specifically to subcellular fractions from C. albicans and stimulated adenylate cyclase activity in C. albicans microsomes. We provide the first demonstration of guanine-nucleotide-binding proteins (G-proteins) in C. albicans, and propose that the stimulation of C. albicans morphogenesis by hLH is mediated by a receptor-coupled adenylate cyclase system involving G-proteins.

UR - http://dx.doi.org/10.1099/00221287-136-11-2143

U2 - 10.1099/00221287-136-11-2143

DO - 10.1099/00221287-136-11-2143

M3 - Article

C2 - 2079618

SN - 0022-1287

VL - 136

SP - 2143

EP - 2148

JO - Journal of General Microbiology

JF - Journal of General Microbiology

IS - 11

ER -

Receptor-mediated elevation of adenylate cyclase by luteinizing hormone in Candida albicans

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