Abstract
The 50-year-old allylboration reaction has seen dramatic developments since the dawn of the new century after the first catalytic asymmetric versions came into play. In the past decade alone, several methodologies capable of achieving the desired homoallylic alcohols in over 90% ee have been developed. This review focuses on the chiral Bronsted acid catalyzed allylboration reaction, covering everything from the very first examples and precedents to modern day variations and applications. 1 Introduction 2 Early Developments 3 Synthetic Applications 4 Variants 5 Computational Contribution 6 Conclusions.
| Original language | English |
|---|---|
| Pages (from-to) | 1935-1957 |
| Number of pages | 23 |
| Journal | Synthesis (Germany) |
| Volume | 50 |
| Issue number | 10 |
| Early online date | 11 Apr 2018 |
| DOIs | |
| Publication status | Published - 17 May 2018 |
Funding
We thank the Spanish MINECO (CTQ2013-43310 and CTQ2017-84249-P) and Generalitat Valenciana (PROMETEOII/2014/073) for their financial support. D.M.S. is grateful to the Spanish Government for an FPU fellowship. We are grateful to Girton College, Cambridge (Research Fellowship to M.N.G.) for financial support.Spanshi Mneistoiri de Economaí y Compvditeiiatd M(NIECO) C(TQ2013-43310G)eneattrail Vaelnacnia P(ROMETEO2/I0I140/73)
Keywords
- allylboration
- asymmetric synthesis
- chiral Bronsted acids
- DFT calculations
- enantioselective catalysis
- homoallylic alcohols
ASJC Scopus subject areas
- Catalysis
- Organic Chemistry
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