Recent advances on transdermal iontophoretic drug delivery and non-invasive sampling

Research output: Contribution to journalReview article

12 Citations (Scopus)

Abstract

Transdermal iontophoresis has become a mature drug delivery technique; iontophoretic devices have been approved by the regulatory agencies for the delivery of fentanyl and lidocaine. Active research investigates other applications for local and systemic drug administration; namely anti-inflammatory drugs, anaesthetics, analgesics, antiviral agents, peptides, proteins, drugs used in photodynamic therapy and to treat Parkinson's disease and migraine. Its potential for non-invasive sampling has found applications in glucose monitoring, therapeutic drug monitoring and pharmacokinetic profiling. The last eight years have brought a better understanding on the mechanisms and pathways of transport during transdermal iontophoresis, oil the selection of drug candidates and the formulation of iontophoretic vehicles. Local effects of iontophoresis are typically moderate to mild oedema and erythema, tingling and itching sensations, and transient elevations of the skin temperature and transepidermal water loss. Iontophoresis is considered a safe, non-invasive and effective way of delivering transdermally judiciously chosen drugs.
Original languageEnglish
Pages (from-to)75-88
Number of pages14
JournalJournal of Drug Delivery Science and Technology
Volume19
Issue number2
DOIs
Publication statusPublished - Mar 2009

Fingerprint

Iontophoresis
Pharmaceutical Preparations
Drug Compounding
Skin Temperature
Drug Monitoring
Photochemotherapy
Fentanyl
Erythema
Pruritus
Lidocaine
Migraine Disorders
Antiviral Agents
Parkinson Disease
Analgesics
Anesthetics
Edema
Oils
Anti-Inflammatory Agents
Pharmacokinetics
Glucose

Keywords

  • Drug delivery
  • Topical
  • Iontophoresis
  • Reverse iontophoresis
  • Transdermal
  • Non-invasive
  • Electromigration
  • Electroosmosis

Cite this

Recent advances on transdermal iontophoretic drug delivery and non-invasive sampling. / Delgado-Charro, Maria B.

In: Journal of Drug Delivery Science and Technology, Vol. 19, No. 2, 03.2009, p. 75-88.

Research output: Contribution to journalReview article

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