Recent advances in therapeutic delivery systems of bacteriophage and bacteriophage-encoded endolysins

Hollie Hathaway, Scarlet Milo, J. Mark Sutton, Toby A. Jenkins

Research output: Contribution to journalReview article

5 Citations (Scopus)
260 Downloads (Pure)

Abstract

Antibiotics have been the cornerstone of clinical management of bacterial infection since their discovery in the early 20th century. However, their widespread and often indiscriminate use has now led to reports of multidrug resistance becoming globally commonplace. Bacteriophage therapy has undergone a recent revival in battle against pathogenic bacteria, as the self-replicating and co-evolutionary features of these predatory virions offer several advantages over conventional therapeutic agents. In particular, the use of targeted bacteriophage therapy from specialized delivery platforms has shown particular promise owing to the control of delivery location, administration conditions and dosage of the therapeutic cargo. This review presents an overview of the recent formulations and applications of such delivery vehicles as an innovative and elegant tool for bacterial control.

Original languageEnglish
Pages (from-to)543-556
Number of pages14
JournalTherapeutic Delivery
Volume8
Issue number7
Early online date21 Jun 2017
DOIs
Publication statusPublished - 1 Jul 2017

Keywords

  • bacteriophage
  • complexation
  • controlled release
  • delivery system
  • encapsulation
  • endolysin
  • immobilization
  • stimuli responsive

ASJC Scopus subject areas

  • Pharmaceutical Science

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