Recent Advances in Enhancement Strategies for Electrochemical ELISA-Based Immunoassays for Cancer Biomarker Detection

Sunil Arya, Pedro Estrela

Research output: Contribution to journalReview article

17 Citations (Scopus)
57 Downloads (Pure)

Abstract

Electrochemical enzyme-linked immunosorbent assay (ELISA)-based immunoassays for cancer biomarker detection have recently attracted much interest owing to their higher sensitivity, amplification of signal, ease of handling, potential for automation and combination with miniaturized analytical systems, low cost and comparative simplicity for mass production. Their developments have considerably improved the sensitivity required for detection of low concentrations of cancer biomarkers present in bodily fluids in the early stages of the disease. Recently, various attempts have been made in their development and several methods and processes have been described for their development, amplification strategies and testing. The present review mainly focuses on the development of ELISA-based electrochemical immunosensors that may be utilized for cancer diagnosis, prognosis and therapy monitoring. Various fabrication methods and signal enhancement strategies utilized during the last few years for the development of ELISA-based electrochemical immunosensors are described.
Original languageEnglish
Article number2010
Pages (from-to)1-45
Number of pages45
JournalSensors
Volume18
Issue number7
DOIs
Publication statusPublished - 22 Jun 2018

Keywords

  • Electrochemical ELISA
  • serum
  • Immunoassay
  • Antibodies
  • cancer
  • Biosensors
  • Cancer detection
  • Serum

ASJC Scopus subject areas

  • Analytical Chemistry
  • Instrumentation
  • Atomic and Molecular Physics, and Optics
  • Electrical and Electronic Engineering
  • Biochemistry

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