Re-emergence of early pandemic Staphylococcus aureus as a community-acquired meticillin-resistant clone

D. Ashley Robinson; Angela M. Kearns; Anne Holmes; Donald Morrison; Hajo Grundmann; Giles Edwards; Frances G. O'Brien; Fred C. Tenover; Linda K. McDougal; Alastair B. Monk; Mark C. Enright

doi:10.1016/S0140-6736(05)74814-5

Re-emergence of early pandemic Staphylococcus aureus as a community-acquired meticillin-resistant clone

D. Ashley Robinson, Angela M. Kearns, Anne Holmes, Donald Morrison, Hajo Grundmann, Giles Edwards, Frances G. O'Brien, Fred C. Tenover, Linda K. McDougal, Alastair B. Monk, Mark C. Enright

Department of Life Sciences

Research output: Contribution to journal › Article › peer-review

233 Citations (SciVal)

Abstract

During the 1950s, the notorious penicillin-resistant clone of Staphylococcus aureus known as phage type 80/81 emerged and caused serious hospital-acquired and community-acquired infections worldwide. This clone was largely eliminated in the 1960s, concurrent with the widespread use of penicillinase-resistant beta lactams. We investigated whether early 80/81 isolates had the genes for Panton-Valentine leucocidin, a toxin associated with virulence in healthy young people. Multilocus sequence analysis suggested that descendants of 80/81 have acquired meticillin resistance, are re-emerging as a community-acquired meticillin-resistant S aureus (MRSA) clone, and represent a sister lineage to pandemic hospital-acquired MRSA.

Original language	English
Pages (from-to)	1256-1258
Number of pages	3
Journal	Lancet
Volume	365
Issue number	9466
DOIs	https://doi.org/10.1016/S0140-6736(05)74814-5
Publication status	Published - 2005

Bibliographical note

ID number: ISI:000228107600029

Keywords

panton-valentine leukocidin
strains
emergence

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10.1016/S0140-6736(05)74814-5

Cite this

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title = "Re-emergence of early pandemic Staphylococcus aureus as a community-acquired meticillin-resistant clone",

abstract = "During the 1950s, the notorious penicillin-resistant clone of Staphylococcus aureus known as phage type 80/81 emerged and caused serious hospital-acquired and community-acquired infections worldwide. This clone was largely eliminated in the 1960s, concurrent with the widespread use of penicillinase-resistant beta lactams. We investigated whether early 80/81 isolates had the genes for Panton-Valentine leucocidin, a toxin associated with virulence in healthy young people. Multilocus sequence analysis suggested that descendants of 80/81 have acquired meticillin resistance, are re-emerging as a community-acquired meticillin-resistant S aureus (MRSA) clone, and represent a sister lineage to pandemic hospital-acquired MRSA.",

keywords = "panton-valentine leukocidin, strains, emergence",

author = "Robinson, {D. Ashley} and Kearns, {Angela M.} and Anne Holmes and Donald Morrison and Hajo Grundmann and Giles Edwards and O'Brien, {Frances G.} and Tenover, {Fred C.} and McDougal, {Linda K.} and Monk, {Alastair B.} and Enright, {Mark C.}",

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volume = "365",

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journal = "Lancet",

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TY - JOUR

T1 - Re-emergence of early pandemic Staphylococcus aureus as a community-acquired meticillin-resistant clone

AU - Robinson, D. Ashley

AU - Kearns, Angela M.

AU - Holmes, Anne

AU - Morrison, Donald

AU - Grundmann, Hajo

AU - Edwards, Giles

AU - O'Brien, Frances G.

AU - Tenover, Fred C.

AU - McDougal, Linda K.

AU - Monk, Alastair B.

AU - Enright, Mark C.

N1 - ID number: ISI:000228107600029

PY - 2005

Y1 - 2005

N2 - During the 1950s, the notorious penicillin-resistant clone of Staphylococcus aureus known as phage type 80/81 emerged and caused serious hospital-acquired and community-acquired infections worldwide. This clone was largely eliminated in the 1960s, concurrent with the widespread use of penicillinase-resistant beta lactams. We investigated whether early 80/81 isolates had the genes for Panton-Valentine leucocidin, a toxin associated with virulence in healthy young people. Multilocus sequence analysis suggested that descendants of 80/81 have acquired meticillin resistance, are re-emerging as a community-acquired meticillin-resistant S aureus (MRSA) clone, and represent a sister lineage to pandemic hospital-acquired MRSA.

AB - During the 1950s, the notorious penicillin-resistant clone of Staphylococcus aureus known as phage type 80/81 emerged and caused serious hospital-acquired and community-acquired infections worldwide. This clone was largely eliminated in the 1960s, concurrent with the widespread use of penicillinase-resistant beta lactams. We investigated whether early 80/81 isolates had the genes for Panton-Valentine leucocidin, a toxin associated with virulence in healthy young people. Multilocus sequence analysis suggested that descendants of 80/81 have acquired meticillin resistance, are re-emerging as a community-acquired meticillin-resistant S aureus (MRSA) clone, and represent a sister lineage to pandemic hospital-acquired MRSA.

KW - panton-valentine leukocidin

KW - strains

KW - emergence

UR - http://dx.doi.org/10.1016/S0140-6736(05)74814-5

U2 - 10.1016/S0140-6736(05)74814-5

DO - 10.1016/S0140-6736(05)74814-5

M3 - Article

SN - 0140-6736

VL - 365

SP - 1256

EP - 1258

JO - Lancet

JF - Lancet

IS - 9466

ER -

Re-emergence of early pandemic Staphylococcus aureus as a community-acquired meticillin-resistant clone

Abstract

Bibliographical note

Keywords

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