Re-emergence of early pandemic Staphylococcus aureus as a community-acquired meticillin-resistant clone

D. Ashley Robinson, Angela M. Kearns, Anne Holmes, Donald Morrison, Hajo Grundmann, Giles Edwards, Frances G. O'Brien, Fred C. Tenover, Linda K. McDougal, Alastair B. Monk, Mark C. Enright

Research output: Contribution to journalArticlepeer-review

218 Citations (Scopus)

Abstract

During the 1950s, the notorious penicillin-resistant clone of Staphylococcus aureus known as phage type 80/81 emerged and caused serious hospital-acquired and community-acquired infections worldwide. This clone was largely eliminated in the 1960s, concurrent with the widespread use of penicillinase-resistant beta lactams. We investigated whether early 80/81 isolates had the genes for Panton-Valentine leucocidin, a toxin associated with virulence in healthy young people. Multilocus sequence analysis suggested that descendants of 80/81 have acquired meticillin resistance, are re-emerging as a community-acquired meticillin-resistant S aureus (MRSA) clone, and represent a sister lineage to pandemic hospital-acquired MRSA.
Original languageEnglish
Pages (from-to)1256-1258
Number of pages3
JournalLancet
Volume365
Issue number9466
DOIs
Publication statusPublished - 2005

Keywords

  • panton-valentine leukocidin
  • strains
  • emergence

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