Ratiometric two-photon fluorescent probe for: In situ imaging of carboxylesterase (CE)-mediated mitochondrial acidification during medication

Ao Jiang, Guang Chen, Jie Xu, Yuxia Liu, Guanghui Zhao, Zhenjun Liu, Tao Chen, Yulin Li, Tony D. James

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68 Citations (SciVal)

Abstract

We report on a dual ratiometric two-photon fluorescent probe for in situ sensing of mitochondrial CE activity and pH. Using the probe it is possible to visualize the CE-mediated acidification of hepatoma cells and hepatic tissues during medication with antipyretic anti-inflammatory drugs.

Original languageEnglish
Pages (from-to)11358-11361
Number of pages4
JournalChemical Communications
Volume55
Issue number76
Early online date3 Sept 2019
DOIs
Publication statusPublished - 28 Sept 2019

Funding

This work was supported by National Natural Science Foundation of China (No. 21475074, and 21403123), the China Postdoctoral Science Foundation (2017M622254; 2016M600531), the Open Funds of the Shandong Province Key Laboratory of Detection Technology for Tumor Markers (KLDTTM2015-6; KLDTTM2015-9), and the Natural Science Foundation of Shan-dong Province (ZR201709240033). T. D. J. thanks the Royal Society for a Wolfson Research Merit Award.

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • General Chemistry
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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