Ratiometric two-photon fluorescent probe for: In situ imaging of carboxylesterase (CE)-mediated mitochondrial acidification during medication

Ao Jiang; Guang Chen; Jie Xu; Yuxia Liu; Guanghui Zhao; Zhenjun Liu; Tao Chen; Yulin Li; Tony D. James

doi:10.1039/c9cc05759e

Ratiometric two-photon fluorescent probe for: In situ imaging of carboxylesterase (CE)-mediated mitochondrial acidification during medication

Ao Jiang, Guang Chen, Jie Xu, Yuxia Liu, Guanghui Zhao, Zhenjun Liu, Tao Chen, Yulin Li, Tony D. James

Department of Chemistry

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68 Citations (SciVal)

Abstract

We report on a dual ratiometric two-photon fluorescent probe for in situ sensing of mitochondrial CE activity and pH. Using the probe it is possible to visualize the CE-mediated acidification of hepatoma cells and hepatic tissues during medication with antipyretic anti-inflammatory drugs.

Original language	English
Pages (from-to)	11358-11361
Number of pages	4
Journal	Chemical Communications
Volume	55
Issue number	76
Early online date	3 Sept 2019
DOIs	https://doi.org/10.1039/c9cc05759e
Publication status	Published - 28 Sept 2019

Funding

This work was supported by National Natural Science Foundation of China (No. 21475074, and 21403123), the China Postdoctoral Science Foundation (2017M622254; 2016M600531), the Open Funds of the Shandong Province Key Laboratory of Detection Technology for Tumor Markers (KLDTTM2015-6; KLDTTM2015-9), and the Natural Science Foundation of Shan-dong Province (ZR201709240033). T. D. J. thanks the Royal Society for a Wolfson Research Merit Award.

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
General Chemistry
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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abstract = "We report on a dual ratiometric two-photon fluorescent probe for in situ sensing of mitochondrial CE activity and pH. Using the probe it is possible to visualize the CE-mediated acidification of hepatoma cells and hepatic tissues during medication with antipyretic anti-inflammatory drugs.",

author = "Ao Jiang and Guang Chen and Jie Xu and Yuxia Liu and Guanghui Zhao and Zhenjun Liu and Tao Chen and Yulin Li and James, {Tony D.}",

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AU - Jiang, Ao

AU - Chen, Guang

AU - Xu, Jie

AU - Liu, Yuxia

AU - Zhao, Guanghui

AU - Liu, Zhenjun

AU - Chen, Tao

AU - Li, Yulin

AU - James, Tony D.

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Ratiometric two-photon fluorescent probe for: In situ imaging of carboxylesterase (CE)-mediated mitochondrial acidification during medication

Abstract

Funding

ASJC Scopus subject areas

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