Ratiometric two-photon fluorescent probe for: In situ imaging of carboxylesterase (CE)-mediated mitochondrial acidification during medication

Ao Jiang, Guang Chen, Jie Xu, Yuxia Liu, Guanghui Zhao, Zhenjun Liu, Tao Chen, Yulin Li, Tony D. James

Research output: Contribution to journalArticle

17 Citations (Scopus)


We report on a dual ratiometric two-photon fluorescent probe for in situ sensing of mitochondrial CE activity and pH. Using the probe it is possible to visualize the CE-mediated acidification of hepatoma cells and hepatic tissues during medication with antipyretic anti-inflammatory drugs.

Original languageEnglish
Pages (from-to)11358-11361
Number of pages4
JournalChemical Communications
Issue number76
Early online date3 Sep 2019
Publication statusPublished - 28 Sep 2019

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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