Ratiometric fluorescent probe for sensing Streptococcus mutans glucosyltransferase, a key factor in the formation of dental caries

Lei Feng; Qingsong Yan; Baojing Zhang; Xiangge Tian; Chao Wang; Zhenlong Yu; Jingnan Cui; Dean Guo; Xiaochi Ma; Tony D. James

doi:10.1039/c9cc00440h

Ratiometric fluorescent probe for sensing Streptococcus mutans glucosyltransferase, a key factor in the formation of dental caries

Lei Feng, Qingsong Yan, Baojing Zhang, Xiangge Tian, Chao Wang, Zhenlong Yu, Jingnan Cui, Dean Guo, Xiaochi Ma, Tony D. James

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

26 Citations (SciVal)

Abstract

We report on a naphthalimide ratiometric fluorescent probe for the real-time sensing and imaging of pathogenic bacterial glucosyltransferases, which are associated with the development of dental caries. Using a high-throughput screening method, we identified that several natural polyphenols from green tea were GTFs inhibitors that could eventually lead to suitable oral treatments to prevent the development of dental caries.

Original language	English
Pages (from-to)	3548-3551
Number of pages	4
Journal	Chemical Communications
Volume	55
Issue number	24
Early online date	25 Feb 2019
DOIs	https://doi.org/10.1039/c9cc00440h
Publication status	Published - 25 Mar 2019

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
General Chemistry
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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10.1039/c9cc00440hLicence: CC BY

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abstract = "We report on a naphthalimide ratiometric fluorescent probe for the real-time sensing and imaging of pathogenic bacterial glucosyltransferases, which are associated with the development of dental caries. Using a high-throughput screening method, we identified that several natural polyphenols from green tea were GTFs inhibitors that could eventually lead to suitable oral treatments to prevent the development of dental caries.",

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AU - Feng, Lei

AU - Yan, Qingsong

AU - Zhang, Baojing

AU - Tian, Xiangge

AU - Wang, Chao

AU - Yu, Zhenlong

AU - Cui, Jingnan

AU - Guo, Dean

AU - Ma, Xiaochi

AU - James, Tony D.

PY - 2019/3/25

Y1 - 2019/3/25

N2 - We report on a naphthalimide ratiometric fluorescent probe for the real-time sensing and imaging of pathogenic bacterial glucosyltransferases, which are associated with the development of dental caries. Using a high-throughput screening method, we identified that several natural polyphenols from green tea were GTFs inhibitors that could eventually lead to suitable oral treatments to prevent the development of dental caries.

AB - We report on a naphthalimide ratiometric fluorescent probe for the real-time sensing and imaging of pathogenic bacterial glucosyltransferases, which are associated with the development of dental caries. Using a high-throughput screening method, we identified that several natural polyphenols from green tea were GTFs inhibitors that could eventually lead to suitable oral treatments to prevent the development of dental caries.

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U2 - 10.1039/c9cc00440h

DO - 10.1039/c9cc00440h

M3 - Article

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ER -

Ratiometric fluorescent probe for sensing Streptococcus mutans glucosyltransferase, a key factor in the formation of dental caries

Abstract

ASJC Scopus subject areas

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