Ratiometric fluorescent probe for sensing Streptococcus mutans glucosyltransferase, a key factor in the formation of dental caries

Lei Feng, Qingsong Yan, Baojing Zhang, Xiangge Tian, Chao Wang, Zhenlong Yu, Jingnan Cui, Dean Guo, Xiaochi Ma, Tony D. James

Research output: Contribution to journalArticle

10 Citations (Scopus)


We report on a naphthalimide ratiometric fluorescent probe for the real-time sensing and imaging of pathogenic bacterial glucosyltransferases, which are associated with the development of dental caries. Using a high-throughput screening method, we identified that several natural polyphenols from green tea were GTFs inhibitors that could eventually lead to suitable oral treatments to prevent the development of dental caries.

Original languageEnglish
Pages (from-to)3548-3551
Number of pages4
JournalChemical Communications
Issue number24
Early online date25 Feb 2019
Publication statusPublished - 25 Mar 2019

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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