Rare myositis-specific autoantibody assocations among Hungarian patients with idiopathic inflammatory myopathy

Levente Bodoki, Melinda Nagy-Vincze, Zoltan Griger, Zoe Betteridge, Laszlone Szollosi, Ravi Jobanputra, Katalin Danko

Research output: Contribution to journalArticlepeer-review


Idiopathic inflammatory myopathies are systemic, chronic autoimmune diseases characterized by symmetrical, proximal muscle weakness. Homogeneous groups present with similar symptoms. The response to therapy and prognosis could be facilitated by myositis-specific autoantibodies, and in this way, give rise to immunoserological classification. The myositis-specific autoantibodies are directed against specific proteins found in the cytoplasm or in the nucleus of the cells. To date, literature suggests the rarity of the co-existence of two myositis-specific autoantibodies. In this study the authors highlight rare associations of myositis-specific autoantibodies. Three hundred and thirty-seven Hungarian patients with polymyositis or dermatomyositis were studied. Their clinical findings were noted retrospectively. Specific blood tests identified six patients with the rare co-existence of myositis-specific autoantibodies, anti-Jo-1 and anti-SRP, anti-Jo-1 and anti-Mi-2, anti-Mi-2 and anti-PL-12, anti-Mi-2 and anti-SRP, and anti-SRP and anti-PL-7, respectively. This case review aims to identify the clinical importance of these rare associations and their place within the immunoserological classification.
Original languageEnglish
Pages (from-to)337-347
JournalActa Reumatologica Portuguesa
Issue number4
Publication statusPublished - 2015


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