Rapid selection for ivermectin resistance in Haemonchus contortus

G C Coles; A C Rhodes; A Wolstenholme

doi:10.1016/j.vetpar.2005.02.002

Rapid selection for ivermectin resistance in Haemonchus contortus

G C Coles
, A C Rhodes
, A Wolstenholme

Department of Life Sciences

Research output: Contribution to journal › Article › peer-review

50 Citations (SciVal)

Abstract

Lambs infected with two isolates, one British and one American, of Haemonchus contortus were treated with increasing doses of ivermectin. Eggs from the highest dose that had not eliminated the infection were cultured and larvae used to infect another lamb. After three generations the H. contortus was resistant to 0.2 mg/kg ivermectin. The results stress the ease with which ivermectin resistance can be selected if high selection pressure is applied. (c) 2005 Elsevier B.V. All rights reserved.

Original language	English
Pages (from-to)	345-347
Number of pages	3
Journal	Veterinary Parasitology
Volume	129
Issue number	3-4
DOIs	https://doi.org/10.1016/j.vetpar.2005.02.002
Publication status	Published - 2005

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ID number: ISI:000229303200020

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10.1016/j.vetpar.2005.02.002

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title = "Rapid selection for ivermectin resistance in Haemonchus contortus",

abstract = "Lambs infected with two isolates, one British and one American, of Haemonchus contortus were treated with increasing doses of ivermectin. Eggs from the highest dose that had not eliminated the infection were cultured and larvae used to infect another lamb. After three generations the H. contortus was resistant to 0.2 mg/kg ivermectin. The results stress the ease with which ivermectin resistance can be selected if high selection pressure is applied. (c) 2005 Elsevier B.V. All rights reserved.",

author = "Coles, \{G C\} and Rhodes, \{A C\} and A Wolstenholme",

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language = "English",

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journal = "Veterinary Parasitology",

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T1 - Rapid selection for ivermectin resistance in Haemonchus contortus

AU - Coles, G C

AU - Rhodes, A C

AU - Wolstenholme, A

N1 - ID number: ISI:000229303200020

PY - 2005

Y1 - 2005

N2 - Lambs infected with two isolates, one British and one American, of Haemonchus contortus were treated with increasing doses of ivermectin. Eggs from the highest dose that had not eliminated the infection were cultured and larvae used to infect another lamb. After three generations the H. contortus was resistant to 0.2 mg/kg ivermectin. The results stress the ease with which ivermectin resistance can be selected if high selection pressure is applied. (c) 2005 Elsevier B.V. All rights reserved.

AB - Lambs infected with two isolates, one British and one American, of Haemonchus contortus were treated with increasing doses of ivermectin. Eggs from the highest dose that had not eliminated the infection were cultured and larvae used to infect another lamb. After three generations the H. contortus was resistant to 0.2 mg/kg ivermectin. The results stress the ease with which ivermectin resistance can be selected if high selection pressure is applied. (c) 2005 Elsevier B.V. All rights reserved.

U2 - 10.1016/j.vetpar.2005.02.002

DO - 10.1016/j.vetpar.2005.02.002

M3 - Article

SN - 0304-4017

VL - 129

SP - 345

EP - 347

JO - Veterinary Parasitology

JF - Veterinary Parasitology

IS - 3-4

ER -

Rapid selection for ivermectin resistance in Haemonchus contortus

Abstract

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